Heintz N H, Dailey L, Held P, Heintz N
Department of Pathology, University of Vermont College of Medicine, Burlington 05405.
Trends Genet. 1992 Nov;8(11):376-81. doi: 10.1016/0168-9525(92)90298-i.
Recent work in yeast shows that eukaryotic origins of DNA replication are multipartite regulatory elements resembling promoters of transcription. As for the regulation of transcription, accessory transcription factors appear to function in concert with basic origin recognition factors to regulate initiation of DNA synthesis at specific subsets of origins. The participation of transcription factors in the regulation of DNA replication may facilitate temporal control of transcription and replication during the cell cycle, as well as providing a mechanism for integrating origin selection with the cellular transcriptional program.
酵母中的最新研究表明，真核生物DNA复制起点是类似于转录启动子的多部分调控元件。与转录调控一样，辅助转录因子似乎与基本的起点识别因子协同作用，以调控特定起点亚群处的DNA合成起始。转录因子参与DNA复制调控可能有助于在细胞周期中对转录和复制进行时间控制，同时也为将起点选择与细胞转录程序整合提供了一种机制。
