Gianutsos G, Seltzer M D, Saymeh R, Wu M L, Michel R G
Arch Toxicol. 1985 Sep;57(4):272-5. doi: 10.1007/BF00324791.
The content and retention of manganese in the blood and brain of mice exposed to different forms of the metal was compared. Mice received an acute sc injection of manganese as the chloride or oxide (Mn3O4) or as the organic MMT. A single injection markedly elevated brain manganese concentrations within 1 day and elevated levels were maintained for at least 21 days. Repeated injections led to further increases in both brain and blood, although the levels in the brain appeared to persist at consistently high levels for longer periods. The chloride form produced higher brain levels than either of the other two forms. These results appear to suggest that the slowly developing neurotoxicity in response to manganese exposure may be due to a persistent retention of manganese by the brain.
比较了暴露于不同形式金属的小鼠血液和大脑中锰的含量及留存情况。小鼠经皮下急性注射氯化锰、氧化锰（Mn3O4）或有机锰添加剂（MMT）。单次注射后1天内大脑锰浓度显著升高，且升高水平至少维持21天。重复注射导致大脑和血液中的锰含量进一步增加，尽管大脑中的水平似乎在较长时间内持续保持在较高水平。氯化物形式产生的大脑锰含量高于其他两种形式中的任何一种。这些结果似乎表明，接触锰后缓慢发展的神经毒性可能是由于大脑对锰的持续留存。
