Buehler P O, Schein O D, Stamler J F, Verdier D D, Katz J
Dana Center for Preventive Ophthalmology, Johns Hopkins University, Baltimore, Md 21287-9012.
Arch Ophthalmol. 1992 Nov;110(11):1555-8. doi: 10.1001/archopht.1992.01080230055019.
Previous controlled studies on contact lens-associated ulcerative keratitis were performed before the widespread use of disposable contact lenses. Therefore, a controlled study was undertaken to determine the relative risk of ulcerative keratitis among users of disposable soft contact lenses compared with the risk among users of other lens types. Forty-six consecutive cases of contact lens-associated ulcerative keratitis were identified between January 1990 and June 1992 at a corneal specialty practice in western Michigan. Five controls, matched to each case patient according to the dispensing data and prescribing practitioner, were obtained for 42 cases (91%). Users of daily-wear rigid gas-permeable lenses had the lowest risk of developing ulcerative keratitis. Relative to users of daily-wear soft contact lenses, users of extended-wear soft contact lens had an age-adjusted and sex-adjusted relative risk of 1.87 (95% confidence interval, 0.61 to 5.71). Disposable soft contact lens users had the highest risk of developing ulcerative keratitis, with an adjusted relative risk of 14.16 (95% confidence interval, 5.47 to 37.63) compared with daily-wear soft contact lens users and 7.66 (95% confidence interval, 2.27 to 25.83) compared with conventional extended-wear soft contact lens users.
以往关于隐形眼镜相关性溃疡性角膜炎的对照研究是在一次性隐形眼镜广泛使用之前进行的。因此，开展了一项对照研究，以确定与其他类型镜片使用者相比，一次性软性隐形眼镜使用者发生溃疡性角膜炎的相对风险。1990年1月至1992年6月期间，在密歇根州西部的一家角膜专科诊所连续确诊了46例隐形眼镜相关性溃疡性角膜炎病例。根据配镜数据和开处方的医生，为其中42例（91%）病例匹配了5名对照。日戴型硬性透气性隐形眼镜使用者发生溃疡性角膜炎的风险最低。与日戴型软性隐形眼镜使用者相比，长戴型软性隐形眼镜使用者经年龄和性别调整后的相对风险为1.87（95%置信区间为0.61至5.71）。一次性软性隐形眼镜使用者发生溃疡性角膜炎的风险最高，与日戴型软性隐形眼镜使用者相比，调整后的相对风险为14.16（95%置信区间为5.47至37.63），与传统长戴型软性隐形眼镜使用者相比，调整后的相对风险为7.66（95%置信区间为2.27至25.83）。
