8-氮杂鸟嘌呤对巨大芽孢杆菌生长和活力的影响。
Effect of 8-azaguanine on growth and viability of Bacillus megaterium.
作者信息
MANGALO R, WACHSMAN J T
出版信息
J Bacteriol. 1962 Jan;83(1):27-34. doi: 10.1128/jb.83.1.27-34.1962.
Abstract
Mangalo, R. (University of Illinois, Urbana) and J. T. Wachsman. Effect of 8-azaguanine on growth and viability of Bacillus megaterium. J. Bacteriol. 83:27-34. 1962.-The addition of 8-azaguanine to exponentially growing cells of Bacillus megaterium results in an inhibition of growth after a lag of approximately 30 min. However, 8-azaguanine-2-C(14) is incorporated into the nucleic acids in a linear fashion without a detectable lag. The inhibitory action is reversed by purines and their derivatives, but not by uridine, thymidine, or cytidine. 8-Azaguanine is bactericidal, especially under conditions where growth (ribonucleic acid synthesis) is possible. Growth in the presence of a complete amino acid mixture, either before or during exposure to 8-azaguanine, increases the rate of killing. Chloramphenicol has little or no effect on the bactericidal action of the analogue.
摘要
曼加洛，R.（伊利诺伊大学厄巴纳分校）和J.T.瓦克斯曼。8-氮杂鸟嘌呤对巨大芽孢杆菌生长和活力的影响。《细菌学杂志》83:27 - 34。1962年。——向指数生长期的巨大芽孢杆菌细胞中添加8-氮杂鸟嘌呤，约30分钟的延迟后会导致生长受到抑制。然而，8-氮杂鸟嘌呤-2-C（14）以线性方式掺入核酸中，没有可检测到的延迟。嘌呤及其衍生物可逆转这种抑制作用，但尿苷、胸苷或胞苷则不能。8-氮杂鸟嘌呤具有杀菌作用，尤其是在可能生长（核糖核酸合成）的条件下。在接触8-氮杂鸟嘌呤之前或期间，在完整氨基酸混合物存在下生长会增加杀灭速率。氯霉素对该类似物的杀菌作用几乎没有影响。
相似文献
1
Effect of 8-azaguanine on growth and viability of Bacillus megaterium.8-氮杂鸟嘌呤对巨大芽孢杆菌生长和活力的影响。
J Bacteriol. 1962 Jan;83(1):27-34. doi: 10.1128/jb.83.1.27-34.1962.
2
Use of 8-azaguanine for the isolation of auxotrophic mutants of Bacillus megaterium.使用8-氮杂鸟嘌呤分离巨大芽孢杆菌的营养缺陷型突变体。
J Bacteriol. 1962 Jan;83(1):35-7. doi: 10.1128/jb.83.1.35-37.1962.
3
Further studies on the modifications of nucleic acid synthesis of B. cereus by 8-azaguanine.关于8-氮杂鸟嘌呤对蜡样芽孢杆菌核酸合成修饰作用的进一步研究。
J Pharmacol Exp Ther. 1961 Aug;133:141-50.
4
Comparative effects of 5-fluorouracil on strains of Bacillus megaterium.5-氟尿嘧啶对巨大芽孢杆菌菌株的比较效应
J Bacteriol. 1964 May;87(5):1011-8. doi: 10.1128/jb.87.5.1011-1018.1964.
5
Chemical and morphological studies of bacterial spore formation. III. The effect of 8-azaguanine on spore and parasporal protein formation in Bacillus cereus var. alesti.细菌芽孢形成的化学与形态学研究。III. 8-氮杂鸟嘌呤对蜡状芽孢杆菌阿莱斯变种芽孢和芽孢旁蛋白形成的影响。
J Biophys Biochem Cytol. 1959 Dec;6(3):499-506. doi: 10.1083/jcb.6.3.499.
6
The depression of the incorporation of sulfur amino acids into Bacillus cereus by 8-Azaguanine.8-氮杂鸟嘌呤对蜡状芽孢杆菌中硫氨基酸掺入的抑制作用。
J Biol Chem. 1960 Jul;235:2029-35.
7
Effect of 8-azaguanine on ribonucleic acid and protein synthesis in Bacillus cereus, NCTC 569.8-氮杂鸟嘌呤对蜡样芽孢杆菌NCTC 569核糖核酸和蛋白质合成的影响
Exp Cell Res. 1960 Oct;21:229-32. doi: 10.1016/0014-4827(60)90370-0.
8
ACCUMULATION OF RIBONUCLEIC ACID IN BACTERIAL NUCLEAR PREPARATIONS DURING TREATMENT OF WHOLE CELLS WITH 8-AZAGUANINE, TETRACYCLINES, AND OTHER INHIBITORS.用8-氮鸟嘌呤、四环素及其他抑制剂处理全细胞时细菌核制剂中核糖核酸的积累
J Bacteriol. 1964 Apr;87(4):755-60. doi: 10.1128/jb.87.4.755-760.1964.
9
Effect of 8-azaguanine on the transition from vegetative growth to presporulation in Bacillus cereus.8-氮杂鸟嘌呤对蜡样芽孢杆菌从营养生长转变为孢子形成前期的影响。
J Bacteriol. 1966 May;91(5):1875-82. doi: 10.1128/jb.91.5.1875-1882.1966.
10
Use of 5-fluorouracil for the isolation of auxotrophic mutants of Bacillus megaterium.利用5-氟尿嘧啶分离巨大芽孢杆菌的营养缺陷型突变体。
J Bacteriol. 1964 May;87(5):1137-9. doi: 10.1128/jb.87.5.1137-1139.1964.
引用本文的文献
1
THYMINELESS INDUCTION OF BACTERIOPHAGE IN BACILLUS MEGATERIUM.巨大芽孢杆菌中噬菌体的无胸腺嘧啶诱导
J Bacteriol. 1964 Nov;88(5):1388-93. doi: 10.1128/jb.88.5.1388-1393.1964.
2
Use of 8-azaguanine for the isolation of auxotrophic mutants of Bacillus megaterium.使用8-氮杂鸟嘌呤分离巨大芽孢杆菌的营养缺陷型突变体。
J Bacteriol. 1962 Jan;83(1):35-7. doi: 10.1128/jb.83.1.35-37.1962.
3
Distinct cistrons for the two ribosomal RNA components.两种核糖体RNA组分的不同顺反子。
Proc Natl Acad Sci U S A. 1963 Apr;49(4):538-44. doi: 10.1073/pnas.49.4.538.
4
Effects of mitomycin C and thymidine deprivation on lysogenic and sensitive strains of Bacillus megaterium.丝裂霉素C和胸腺嘧啶核苷剥夺对巨大芽孢杆菌溶源性菌株和敏感菌株的影响。
J Bacteriol. 1967 Oct;94(4):1088-92. doi: 10.1128/jb.94.4.1088-1092.1967.
5
Use of 5-fluorouracil for the isolation of auxotrophic mutants of Bacillus megaterium.利用5-氟尿嘧啶分离巨大芽孢杆菌的营养缺陷型突变体。
J Bacteriol. 1964 May;87(5):1137-9. doi: 10.1128/jb.87.5.1137-1139.1964.
6
Use of thymineless death to enrich for doubly auxotrophic mutants of Bacillus megaterium.利用无胸腺嘧啶死亡法富集巨大芽孢杆菌的双营养缺陷型突变体。
J Bacteriol. 1964 May;87(5):1118-22. doi: 10.1128/jb.87.5.1118-1122.1964.
7
Thymineless death in Bacillus megaterium.巨大芽孢杆菌中的胸腺嘧啶饥饿死亡
J Bacteriol. 1964 May;87(5):1079-86. doi: 10.1128/jb.87.5.1079-1086.1964.
8
Comparative effects of 5-fluorouracil on strains of Bacillus megaterium.5-氟尿嘧啶对巨大芽孢杆菌菌株的比较效应
J Bacteriol. 1964 May;87(5):1011-8. doi: 10.1128/jb.87.5.1011-1018.1964.
9
Mechanism of counteraction of aflatoxin toxicity by thymine and folic acid in Bacillus megaterium.胸腺嘧啶和叶酸对巨大芽孢杆菌中黄曲霉毒素毒性的拮抗机制。
Folia Microbiol (Praha). 1986;31(4):272-6. doi: 10.1007/BF02926950.
10
Mutant enrichment in the colonial alga, Eudorina elegans.群居绿藻美丽团藻中的突变体富集现象。
Genetics. 1975 Oct;81(2):243-51. doi: 10.1093/genetics/81.2.243.
本文引用的文献
1
THE MECHANISM OF BACTERIAL FRAGILITY PRODUCED BY 5-FLUOROURACIL: THE ACCUMULATION OF CELL WALL PRECURSORS.5-氟尿嘧啶导致细菌脆弱性的机制：细胞壁前体的积累。
Proc Natl Acad Sci U S A. 1960 Mar;46(3):324-7. doi: 10.1073/pnas.46.3.324.
2
On the inhibition of phage production by 2-thiouracil and 8-azaguanine in an induced lysogenic Bacillus megaterium.2-硫尿嘧啶和8-氮鸟嘌呤对诱导性溶源性巨大芽孢杆菌噬菌体产生的抑制作用
Biochim Biophys Acta. 1959 Sep;35:166-79. doi: 10.1016/0006-3002(59)90345-2.
3
Use of 8-azaguanine for the isolation of auxotrophic mutants of Bacillus megaterium.使用8-氮杂鸟嘌呤分离巨大芽孢杆菌的营养缺陷型突变体。
J Bacteriol. 1962 Jan;83(1):35-7. doi: 10.1128/jb.83.1.35-37.1962.
4
Effects of 8-azaguanine on the synthesis of protein and nucleic acids in Bacillus cereus.8-氮杂鸟嘌呤对蜡样芽孢杆菌蛋白质和核酸合成的影响。
Nature. 1958 Jun 21;181(4625):1737-8. doi: 10.1038/1811737a0.
5
On the use of chloramphenicol-inhibited systems for investigating RNA and protein synthesis.关于使用氯霉素抑制系统研究RNA和蛋白质合成
Biochim Biophys Acta. 1958 Jul;29(1):214-5. doi: 10.1016/0006-3002(58)90170-7.
6
Metabolic instability of the ribonucleic acid synthesized by Escherichia coli in the presence of chloromycetin.大肠杆菌在氯霉素存在的情况下合成的核糖核酸的代谢不稳定性。
Biochim Biophys Acta. 1957 Sep;25(3):513-20. doi: 10.1016/0006-3002(57)90521-8.
7
The metabolism of 8-azapurines.8-氮杂嘌呤的代谢
Biochem J. 1957 Jun;66(2):323-33. doi: 10.1042/bj0660323.
8
Incorporation of 8-azaguanine and growth inhibition Bacillus cereus.8-氮杂鸟嘌呤的掺入与蜡样芽孢杆菌的生长抑制
J Biol Chem. 1957 Mar;225(1):137-50.
9
A study of the ribonucleic acid of normal and chloromycetin-inhibited bacteria by zone electrophoresis.通过区带电泳对正常细菌和氯霉素抑制细菌的核糖核酸进行的研究。
Biochim Biophys Acta. 1957 Jan;23(1):162-73. doi: 10.1016/0006-3002(57)90299-8.
10
The assimilation of amino acids by bacteria. 22. The effect of 8-azaguanine upon enzyme formation in Staphylococcus aureus.细菌对氨基酸的同化作用。22. 8-氮杂鸟嘌呤对金黄色葡萄球菌中酶形成的影响。
Biochem J. 1956 Nov;64(3):539-45. doi: 10.1042/bj0640539.
Zotero 插件