Vishwanath P, Basappa S C, Murthy V S
Folia Microbiol (Praha). 1986;31(4):272-6. doi: 10.1007/BF02926950.
Thymine and cytosine as well as the intermediates in pyrimidine biosynthetic pathway dihydroorotic acid, orotic acid, carbamyl aspartate and 5'-uridine monophosphate and folic acid, was synergistic. 2-14C-Thymine, 6-14C-orotic acid and 14C-formate but not 2-14C-uracil, were incorporated into DNA more in the presence of aflatoxin. These findings indicated that aflatoxin inhibited the pyrimidine base synthesis which could be overcome to a great extent by the addition of thymine and folic acid to aflatoxin-treated cells.
胸腺嘧啶、胞嘧啶以及嘧啶生物合成途径中的中间体二氢乳清酸、乳清酸、氨甲酰天冬氨酸和5'-尿苷单磷酸与叶酸具有协同作用。在黄曲霉毒素存在的情况下，2-¹⁴C-胸腺嘧啶、6-¹⁴C-乳清酸和¹⁴C-甲酸而非2-¹⁴C-尿嘧啶更多地掺入到DNA中。这些发现表明，黄曲霉毒素抑制嘧啶碱基合成，而向经黄曲霉毒素处理的细胞中添加胸腺嘧啶和叶酸可在很大程度上克服这种抑制作用。
