NEU H C, RANDALL H G, OSLER A G
Immunology. 1961 Oct;4(4):401-12.
A series of exploratory studies have been described in which an isometric apparatus has been applied to the study of the smooth muscle response to immune reactions. Data are given for the dose-response relationships with several immune systems. Evidence is provided which relates the length of the induction period to the quantity of antigen and magnitude of the smooth muscle response. Segments of small intestine of some, but not all, guinea pigs react to the presence of rabbit anti-γ globulin. The differences that have been encountered may be due to genetic variation in guinea-pig γ globulins. Previous findings have been confirmed that normal γ globulins may interfere with the sensitization of tissue or with the tissue response due to specific antibody. sensitization of guinea-pig small intestine demonstrated that the smooth muscle response to one immune system may diminish a subsequent response of the same tissue to an unrelated antigen-antibody reaction.
已经描述了一系列探索性研究，其中一种等长装置已被用于研究平滑肌对免疫反应的应答。给出了与几种免疫系统的剂量-反应关系的数据。提供的证据表明诱导期的长短与抗原量及平滑肌反应的大小有关。部分（但不是全部）豚鼠的小肠段对兔抗γ球蛋白的存在有反应。所遇到的差异可能是由于豚鼠γ球蛋白的基因变异。先前的研究结果得到了证实，即正常γ球蛋白可能会干扰组织的致敏作用或因特异性抗体引起的组织反应。豚鼠小肠致敏实验表明，平滑肌对一种免疫系统的反应可能会减弱同一组织随后对无关抗原-抗体反应的反应。
