Zschäbitz A, Neurath M, Grevenstein J, Koepp H, Stofft E
Department of Anatomy, Johannes Gutenberg-University, Mainz, Federal Republic of Germany.
Surg Endosc. 1992 Nov-Dec;6(6):277-82. doi: 10.1007/BF02498859.
The correlation between arthroscopic observations and histologic changes in rheumatoid arthritis is still controversial. Synovial samples of 21 knee joints in rheumatoid arthritis patients were comparatively investigated by endoscopy and histology. Biopsies were scored by an endoscopist and subsequently dissected. Different histochemical and immunocytochemical staining techniques were used to define inflammatory activity. Arthroscopic and histological values were compared by rating scales and variance analysis. Our study indicates that synovial biopsy is of diagnostic value in rheumatoid arthritis. However, its usefulness depends on the histochemical methods used. The results revealed highly significant correlations of endoscopic features with the number of neutrophilic granulocytes, intravascular leukocytes, and peroxidase-positive macrophages. However, no relationship was found between the detection of lymphocytes or resident macrophages and inflammatory scores. The close correlation between endoscopic and histological findings suggests that arthroscopic evaluation allows a valuable classification of the inflammatory activity in rheumatoid synovitis.
类风湿性关节炎关节镜观察结果与组织学变化之间的相关性仍存在争议。对21例类风湿性关节炎患者膝关节的滑膜样本进行了内镜检查和组织学对比研究。活检由内镜医师评分，随后进行解剖。采用不同的组织化学和免疫细胞化学染色技术来确定炎症活性。通过评分量表和方差分析对关节镜检查和组织学数据进行比较。我们的研究表明，滑膜活检在类风湿性关节炎中具有诊断价值。然而，其效用取决于所使用的组织化学方法。结果显示，内镜特征与中性粒细胞、血管内白细胞及过氧化物酶阳性巨噬细胞数量之间存在高度显著的相关性。然而，淋巴细胞或常驻巨噬细胞的检测与炎症评分之间未发现关联。内镜检查结果与组织学结果之间的密切相关性表明，关节镜评估可为类风湿性滑膜炎的炎症活性提供有价值的分类。
