出血性猪中高渗盐水/右旋糖酐的最佳剂量
Optimal dose of hypertonic saline/dextran in hemorrhaged swine.
作者信息
Wade Charles E, Dubick Michael A, Grady J J
机构信息
BioPhausia AB, Uppsala, Sweden.
出版信息
J Trauma. 2003 Sep;55(3):413-6. doi: 10.1097/01.TA.0000057247.02378.5E.
BACKGROUND
Hypertonic saline/dextran (HSD) fluid resuscitation has been demonstrated to be effective in alleviating the adverse effects of hemorrhagic hypotension. The optimal dose of HSD has not been defined.
METHODS
he comparative effectiveness of various dosages of HSD for the treatment of severe hemorrhage was investigated in conscious swine bled 46 mL/kg over 15 minutes, a lethal procedure. Five minutes after the completion of hemorrhage, animals were treated with 1, 2, 4, or 11.5 mL/kg HSD and observed over the next 96 hours.
RESULTS
The 11.5-mL dose resulted in 100% survival, which was statistically superior to the 1- and 2-mL doses but not the 4-mL dose. Survival incidences with 4, 2, and 1 mL/kg were 83%, 64%, and 13%, respectively.
CONCLUSION
In terms of survival time, the 11.5- and 4-mL/kg doses were not significantly different. Therefore, optimum resuscitative effectiveness of HSD is achieved within the dose range of 4 to 11.5 mL/kg.
背景
高渗盐水/右旋糖酐（HSD）液体复苏已被证明在减轻出血性低血压的不良反应方面是有效的。HSD的最佳剂量尚未确定。
方法
在有意识的猪身上进行研究，这些猪在15分钟内失血46 mL/kg，这是一个致死性过程，以此来探究不同剂量的HSD治疗严重出血的相对有效性。出血完成后5分钟，给动物注射1、2、4或11.5 mL/kg的HSD，并在接下来的96小时内进行观察。
结果
11.5 mL的剂量导致100%存活，这在统计学上优于1 mL和2 mL的剂量，但不优于4 mL的剂量。4、2和1 mL/kg剂量的存活发生率分别为83%、64%和13%。
结论
就存活时间而言，11.5 mL/kg和4 mL/kg的剂量没有显著差异。因此，在4至11.5 mL/kg的剂量范围内可实现HSD的最佳复苏效果。
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