Kane Michael A C
Manhattan Eye, Ear and Throat Hospital, New York, NY, USA.
Plast Reconstr Surg. 2003 Oct;112(5 Suppl):66S-72S; discussion 73S-74S. doi: 10.1097/01.PRS.0000082195.44980.10.
The use of botulinum toxin A (Botox; Allergan, Irvine, Calif.) for cosmetic purposes was first described in the medical literature in 1992. The author has been using botulinum toxin A in his practice for cosmetic purposes since 1991. In May of 1992, he began using Botox for improvement of the nasolabial folds. An experience of over 1000 injections to the nasolabial folds in more than 200 unique patients is presented. Technique and selection criteria have changed greatly during the past 10 years, and this evolution is discussed. The keys to achieving adequate correction and satisfied patients when treating the nasolabial fold are proper diagnosis of what is causing the fold and careful patient selection.
1992年，医学文献首次描述了将A型肉毒杆菌毒素（保妥适；艾尔建公司，加利福尼亚州欧文市）用于美容目的。自1991年起，作者便在其临床实践中使用A型肉毒杆菌毒素进行美容。1992年5月，他开始使用保妥适来改善鼻唇沟。本文介绍了在200多名不同患者身上进行1000多次鼻唇沟注射的经验。在过去10年中，技术和选择标准发生了很大变化，本文将对此演变过程进行讨论。治疗鼻唇沟时，实现充分矫正并让患者满意的关键在于正确诊断导致鼻唇沟出现的原因以及谨慎选择患者。
