Wätzig V, Ruffert K
Allerg Immunol (Leipz). 1977;23(2):69-78.
In the leucocyte migration inhibition test in the skin chamber under in vivo conditions an immune reaction is induced, which influences the migration of polymorphonuclear neutrophilic leucocytes into the chamber in a characteristic way. An inhibition of the migration of leucocytes above 40 per cent is considered positive. In 16 out of 17 patients with chloramphenicol exanthema the test was positive. Five allergic patients with eczematous skin lesions presented negative results. In 14 controlpatients chloramphenicol caused a negative result, too. The mechanical irritation of the skin and the immune response produce different mechanisms, which promote and inhibit migration. The observed influence of the number of leukocyte in the skin chamber is the result of these mechanisms.
在体内条件下皮肤小室白细胞迁移抑制试验中，可诱导免疫反应，该反应以一种特征性方式影响多形核中性白细胞向小室的迁移。白细胞迁移抑制超过40%被认为是阳性。17例氯霉素疹患者中有16例试验呈阳性。5例患有湿疹性皮肤损害的过敏患者结果为阴性。14例对照患者使用氯霉素后结果也为阴性。皮肤的机械刺激和免疫反应产生不同的机制，这些机制促进和抑制迁移。在皮肤小室中观察到的白细胞数量的影响就是这些机制的结果。
