Münks S
Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Plastische Operationen, Caritas-Klinik St. Theresia, Saarbrücken.
Laryngorhinootologie. 2003 Sep;82(9):655-8. doi: 10.1055/s-2003-42683.
A case of a 76-year-old-man is reported who was referred to the department because of an increasing tumor of the right nasal cavity. After surgical treatment of the neoplasm histological examination revealed a solitary fibrous tumor (SFT) of the nasal mucosa.
Solitary fibrous tumors mostly occur as pleural neoplasms. Extrapleural locations of this mesenchymal tumor species are rarely found in the head and neck region. These extrapleural tumors are sometimes difficult to diagnose because of their histologic variability. Solitary fibrous tumors typically show intense staining for CD 34, vimentin, bcl-2 and sometimes for desmin. These immunohistochemical features have made differentiation from other lesions in the head and neck region much easier. Most pleural and extrapleural solitary fibrous tumors behave in a benign fashion with good prognosis, though aggressive lesions with local invasion or distant metastases have been reported. Definitive surgical treatment with complete tumor removal is recommended in literature. Encouraging chemotherapy or radiotherapy results have not been reported so far.
报告一例76岁男性病例，该患者因右侧鼻腔肿瘤增大被转诊至该科室。肿瘤经手术治疗后，组织学检查显示为鼻黏膜孤立性纤维瘤（SFT）。
孤立性纤维瘤大多表现为胸膜肿瘤。这种间叶性肿瘤在胸膜外的部位很少见于头颈部区域。这些胸膜外肿瘤有时因其组织学变异性而难以诊断。孤立性纤维瘤通常对CD 34、波形蛋白、bcl-2呈强阳性染色，有时对结蛋白也呈阳性染色。这些免疫组化特征使得与头颈部其他病变的鉴别变得容易得多。大多数胸膜和胸膜外孤立性纤维瘤表现为良性，预后良好，不过也有报道称存在具有局部侵袭或远处转移的侵袭性病变。文献推荐采用完整切除肿瘤的确定性手术治疗。目前尚未有关于化疗或放疗取得令人鼓舞结果的报道。
