Lin Pao-Hwa, Ginty Fiona, Appel Lawrence J, Aickin Mikel, Bohannon Arline, Garnero Patrick, Barclay Denis, Svetkey Laura P
Department of Medicine, Sarah W. Stedman Center for Nutritional Studies, Duke University Medical Center, Durham, NC, USA.
J Nutr. 2003 Oct;133(10):3130-6. doi: 10.1093/jn/133.10.3130.
Dietary strategies to prevent and treat osteoporosis focus on increased intake of calcium and vitamin D. Modification of whole dietary patterns and sodium reduction may also be effective. We examined the effects of two dietary patterns and three sodium levels on bone and calcium metabolism in a randomized feeding study. A total of 186 adults, aged 23-76 y, participated. After a 2-wk run-in period, participants were assigned randomly to diets containing three levels of sodium (50, 100 and 150 mmol/d) to be consumed for 30 d in random order. Serum osteocalcin (OC), C-terminal telopeptide of type I collagen (CTX), fasting serum parathyroid hormone (PTH), urinary sodium, potassium, calcium and cAMP were measured at baseline and at the end of each sodium period. The Dietary Approaches to Stop Hypertension (DASH) diet reduced serum OC by 8-11% and CTX by 16-18% (both P < 0.001). Urinary calcium excretion did not differ between subjects that consumed the DASH and control diets. Reducing sodium from the high to the low level significantly decreased serum OC 0.6 microg/L in subjects that consumed the DASH diet, fasting serum PTH 2.66 ng/L in control subjects and urinary calcium 0.5 mmol/24 h in both groups. There were no consistent effects of the diets or sodium levels on urinary cAMP. In conclusion, the DASH diet significantly reduced bone turnover, which if sustained may improve bone mineral status. A reduced sodium intake reduced calcium excretion in both diet groups and serum OC in the DASH group. The DASH diet and reduced sodium intake may have complementary, beneficial effects on bone health.
预防和治疗骨质疏松症的饮食策略主要集中在增加钙和维生素D的摄入量。调整整体饮食模式和减少钠摄入也可能有效。在一项随机喂养研究中，我们研究了两种饮食模式和三种钠水平对骨骼和钙代谢的影响。共有186名年龄在23至76岁之间的成年人参与。经过2周的导入期后，参与者被随机分配到含有三种钠水平（50、100和150 mmol/d）的饮食中，按随机顺序食用30天。在基线和每个钠摄入期结束时测量血清骨钙素（OC）、I型胶原C端肽（CTX）、空腹血清甲状旁腺激素（PTH）、尿钠、钾、钙和cAMP。终止高血压膳食疗法（DASH）饮食使血清OC降低了8 - 11%，CTX降低了16 - 18%（均P < 0.001）。食用DASH饮食和对照饮食的受试者之间尿钙排泄没有差异。将钠从高水平降至低水平可使食用DASH饮食的受试者血清OC显著降低0.6 μg/L，使对照受试者空腹血清PTH降低2.66 ng/L，两组的尿钙均降低0.5 mmol/24 h。饮食或钠水平对尿cAMP没有一致的影响。总之，DASH饮食显著降低了骨转换，如果持续下去可能会改善骨矿物质状况。减少钠摄入可降低两个饮食组的钙排泄，并降低DASH组的血清OC。DASH饮食和减少钠摄入可能对骨骼健康具有互补的有益作用。
