Toker Ebru, Yenice Ozlem, Temel Ahmet
Marmara University Medical School, Department of Ophthalmology, Istanbul, Turkey.
J Glaucoma. 2003 Oct;12(5):436-40. doi: 10.1097/00061198-200310000-00007.
The purpose of this study was to assess the effect that changes in sex hormone levels have on intraocular pressure (IOP) in menopausal women.
Thirty menopausal women on hormone replacement therapy and 32 menopausal women who had never received hormone replacement therapy (HRT), matched for age and duration of amenorrhea, participated in this study. Intraocular pressures were measured with Goldmann applanation tonometer. Serum levels were measured for estradiol, free testosterone, and follicle stimulating hormone (FSH). The influence of serum hormone levels on IOP was assessed by correlation analysis.
The mean IOP of postmenopausal women receiving HRT (13.29 +/- 2.28 mm Hg) was not significantly different from that of menopausal women not receiving HRT (13.56 +/- 2.5 mm Hg, P = 0.24). Higher testosterone levels were associated with higher IOPs in women receiving HRT (r = 0.48, P = 0.02) and in those not receiving HRT (r =0.42, P = 0.003). No significant correlations were observed between IOP and serum levels of estradiol and FSH in either group.
Our data provide evidence for a relation between serum testosterone levels and IOP in menopause. Higher testosterone seems to have a tendency to increase IOP in menopausal women.
本研究旨在评估性激素水平变化对绝经后女性眼压（IOP）的影响。
30名接受激素替代疗法的绝经后女性和32名从未接受过激素替代疗法（HRT）的绝经后女性参与了本研究，两组在年龄和闭经时间上相匹配。使用Goldmann压平眼压计测量眼压。检测血清雌二醇、游离睾酮和促卵泡激素（FSH）水平。通过相关性分析评估血清激素水平对眼压的影响。
接受HRT的绝经后女性的平均眼压（13.29 +/- 2.28 mmHg）与未接受HRT的绝经后女性的平均眼压（13.56 +/- 2.5 mmHg，P = 0.24）无显著差异。在接受HRT的女性（r = 0.48，P = 0.02）和未接受HRT的女性（r = 0.42，P = 0.003）中，较高的睾酮水平与较高的眼压相关。两组中眼压与血清雌二醇和FSH水平均未观察到显著相关性。
我们的数据为绝经后血清睾酮水平与眼压之间的关系提供了证据。较高的睾酮似乎有使绝经后女性眼压升高的趋势。
