de Sanjose Silvia, Almirall Rosa, Lloveras Belen, Font Rebeca, Diaz Mireia, Muñoz Nubia, Català Isabel, Meijer Chris J L M, Snijders Peter J F, Herrero Rolando, Bosch F Xavier
Servei d'Epidemiologia i Registre del Cancer, Institut Catala d'Oncologia, Gran Via km 2.7 E-08907 L'Hospitalet de Llobregat, Barcelona, Spain.
Sex Transm Dis. 2003 Oct;30(10):788-93. doi: 10.1097/01.OLQ.0000080177.82204.E0.
Human papillomavirus (HPV) is a major cause of invasive cervical cancer. Identification of HPV determinants might allow for targeting of high-risk groups for cervical cancer.
The goal was to estimate the HPV prevalence and its determinants among women from the general population of Barcelona.
We studied a random sample of female residents in metropolitan Barcelona, Spain (n = 973). Information was obtained through personal interviews and laboratory testing of cervical exfoliated cells. HPV was detected using a GP5+/6+ polymerase chain reaction assay.
The average age of participants was 43 years (standard deviation = 16.1 y) and the percentage of lifetime monogamy was 79%. The age-adjusted HPV prevalence was 3.0%. Independent HPV determinants were being born overseas (odds ratio [OR], 8.1; 95% confidence interval [CI], 1.9-33.5), being divorced (OR, 6.7; 95% CI, 1.9-24.3), reporting more than one sexual partner (OR, 2.6; 95% CI, 1.0-6.5), and smoking marijuana and related products (OR, 5.2; 95% CI, 1.2-21.7). Use of condoms with regular partner was protective (OR, 0.14; 95% CI, 0.02-1.0).
The study confirms a low overall HPV prevalence in a largely monogamous population. The protection observed with condom use needs further evaluation.
人乳头瘤病毒（HPV）是浸润性宫颈癌的主要病因。确定HPV的决定因素可能有助于针对宫颈癌高危人群进行干预。
本研究旨在估计巴塞罗那普通人群中女性HPV的感染率及其决定因素。
我们对西班牙巴塞罗那市的女性居民进行了随机抽样研究（n = 973）。通过个人访谈和宫颈脱落细胞的实验室检测获取信息。采用GP5+/6+聚合酶链反应检测法检测HPV。
参与者的平均年龄为43岁（标准差 = 16.1岁），一生坚持一夫一妻制的比例为79%。年龄调整后的HPV感染率为3.0%。HPV的独立决定因素包括出生在国外（比值比[OR]，8.1；95%置信区间[CI]，1.9 - 33.5）、离婚（OR，6.7；95% CI，1.9 - 24.3）、有多个性伴侣（OR，2.6；95% CI，1.0 - 6.5）以及吸食大麻及相关制品（OR，5.2；95% CI，1.2 - 21.7）。与固定性伴侣使用避孕套具有保护作用（OR，0.14；95% CI，0.02 - 1.0）。
该研究证实，在一夫一妻制为主的人群中，HPV总体感染率较低。使用避孕套的保护作用有待进一步评估。
