Peterson J, Lagiou P, Samoli E, Lagiou A, Katsouyanni K, La Vecchia C, Dwyer J, Trichopoulos D
Schools of Nutrition and Medicine, Boston, MA 02111, USA.
Br J Cancer. 2003 Oct 6;89(7):1255-9. doi: 10.1038/sj.bjc.6601271.
Flavonoids have been investigated for possible inverse associations with various chronic degenerative diseases, but there are no epidemiologic data concerning a possible association between several of the main flavonoid categories and breast cancer risk. We have applied recently published data on the flavonoid content of several foods and beverages on dietary information collected in the context of a large case-control study of 820 women with breast cancer and 1548 control women, conducted in Greece. We found a strong, statistically significant inverse association of flavone intake with breast cancer. The odds ratio for an increment equal to one standard deviation of daily flavone intake (i.e. 0.5 mg day(-1)) was 0.87, with 95% confidence interval 0.77-0.97. The association persisted after controlling for fruit and vegetable consumption, or for other flavonoid intake. This inverse association is compatible with and may explain the reported inverse association of breast cancer with consumption of vegetables, particularly leafy vegetables. After controlling for dietary confounding, there was no association of breast cancer risk with flavanones, flavan-3-ols, flavonols, anthocyanidins or isoflavones.
黄酮类化合物已被研究是否与各种慢性退行性疾病存在负相关，但尚无流行病学数据表明几种主要黄酮类化合物与乳腺癌风险之间可能存在关联。我们利用最近发表的关于几种食物和饮料中黄酮类化合物含量的数据，结合在希腊进行的一项针对820名乳腺癌女性和1548名对照女性的大型病例对照研究中收集的饮食信息。我们发现黄酮摄入量与乳腺癌之间存在强烈的、具有统计学意义的负相关。每日黄酮摄入量增加一个标准差（即0.5毫克/天）的比值比为0.87，95%置信区间为0.77-0.97。在控制了水果和蔬菜摄入量或其他黄酮类化合物摄入量后，这种关联仍然存在。这种负相关与报道的乳腺癌与蔬菜（特别是叶菜类蔬菜）消费之间的负相关相符，并且可能解释了这种负相关。在控制饮食混杂因素后，乳腺癌风险与黄烷酮、黄烷-3-醇、黄酮醇、花青素或异黄酮之间没有关联。
