al-Dawoud A, Nakshabendi I, Foulis A, Mowat A M
Department of Pathology, Royal Infirmary, Glasgow.
Gut. 1992 Nov;33(11):1482-6. doi: 10.1136/gut.33.11.1482.
The role of gamma-interferon in the pathogenesis of enteropathies with an immunological basis such as coeliac disease, is unclear. Gamma-interferon immunoreactive lymphocytes were quantified in jejunal biopsies from patients with coeliac disease and from normal controls. In coeliac disease, there was an apparent decrease in the percentage of both intraepithelial (3.5% v 13.5%) and lamina propria (10.3% v 47.2%) lymphocytes expressing gamma-interferon compared with controls. In patients successfully treated with a gluten free diet, the percentage of gamma-interferon immunoreactive intra-epithelial lymphocytes was 10.3%. Intraepithelial lymphocytes were immunonegative for class II major histocompatibility complex, while epithelial cells showed increased expression of this product in coeliac disease. The results show that a relatively large proportion of lymphocytes in normal small bowel express gamma-interferon. They also indicate that in coeliac disease the major increase in the numbers of mucosal lymphocytes is the result of infiltration by lymphocytes not expressing gamma-interferon.
γ-干扰素在具有免疫基础的肠病（如乳糜泻）发病机制中的作用尚不清楚。对乳糜泻患者和正常对照者的空肠活检组织中γ-干扰素免疫反应性淋巴细胞进行了定量分析。与对照组相比，乳糜泻患者上皮内（3.5%对13.5%）和固有层（10.3%对47.2%）表达γ-干扰素的淋巴细胞百分比明显降低。成功采用无麸质饮食治疗的患者，上皮内γ-干扰素免疫反应性淋巴细胞百分比为10.3%。上皮内淋巴细胞对Ⅱ类主要组织相容性复合体呈免疫阴性，而在乳糜泻中上皮细胞该产物的表达增加。结果表明，正常小肠中相对较大比例的淋巴细胞表达γ-干扰素。它们还表明，在乳糜泻中，黏膜淋巴细胞数量的主要增加是不表达γ-干扰素的淋巴细胞浸润的结果。
