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1
The effect of gluten on HLA-DR in the small intestinal epithelium of patients with coeliac disease.麸质对乳糜泻患者小肠上皮中HLA - DR的影响。
Clin Exp Immunol. 1986 Jan;63(1):101-4.
2
HLA-DR, DP and DQ expression in the small intestine of patients with coeliac disease.乳糜泻患者小肠中HLA - DR、DP和DQ的表达
Clin Exp Immunol. 1987 Nov;70(2):386-93.
3
Relation between HLA-DR-like antigens and secretory component (SC) in jejunal epithelium of patients with coeliac disease or dermatitis herpetiformis.乳糜泻或疱疹样皮炎患者空肠上皮中HLA-DR样抗原与分泌成分（SC）的关系。
Clin Exp Immunol. 1981 May;44(2):233-8.
4
Gluten intolerance (coeliac disease).麸质不耐受（乳糜泻）。
Ann Allergy. 1984 Dec;53(6 Pt 2):637-42.
5
HLA-DR expression, natural killer cells and IgE containing cells in the jejunal mucosa of coeliac children.乳糜泻患儿空肠黏膜中的人类白细胞抗原-DR表达、自然杀伤细胞及含免疫球蛋白E的细胞
Gut. 1987 Aug;28(8):988-94. doi: 10.1136/gut.28.8.988.
6
Gliadin induced changes in the expression of MHC-class II antigens by human small intestinal epithelium. Organ culture studies with coeliac disease mucosa.麦醇溶蛋白诱导人小肠上皮细胞中MHC-II类抗原表达的变化。乳糜泻黏膜的器官培养研究。
Gut. 1992 Apr;33(4):472-5. doi: 10.1136/gut.33.4.472.
7
Gluten stimulation of coeliac mucosa in vitro induces activation (CD25) of lamina propria CD4+ T cells and macrophages but no crypt-cell hyperplasia.麸质在体外对乳糜泻黏膜的刺激可诱导固有层CD4+ T细胞和巨噬细胞的激活（CD25），但不会导致隐窝细胞增生。
Scand J Immunol. 1993 Dec;38(6):581-90. doi: 10.1111/j.1365-3083.1993.tb03245.x.
8
The distribution of gluten-sensitive lymphocytes in coeliac patients--is it related to dietary gluten?乳糜泻患者中麸质敏感淋巴细胞的分布——它与饮食中的麸质有关吗？
Clin Exp Immunol. 1986 Nov;66(2):393-8.
9
Proceedings: Immunological phenomena following gluten challenge in the jejunum of patients with adult coeliac disease and dermatitis herpetiformis.研究报告：成年乳糜泻和疱疹样皮炎患者空肠内麸质激发后的免疫现象
Gut. 1974 Apr;15(4):339.
10
Lymphocyte subpopulations in the human small intestine. The findings in normal mucosa and in the mucosa of patients with adult coeliac disease.人类小肠中的淋巴细胞亚群。正常黏膜及成人乳糜泻患者黏膜中的研究结果。
Clin Exp Immunol. 1983 Apr;52(1):219-28.

引用本文的文献

1
Emerging technologies in upper gastrointestinal endoscopy and celiac disease.上消化道内镜检查与乳糜泻的新兴技术
Nat Clin Pract Gastroenterol Hepatol. 2009 Jan;6(1):47-56. doi: 10.1038/ncpgasthep1298. Epub 2008 Nov 11.
2
Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells.人肠道上皮细胞高度极化的HLA-II类抗原加工与呈递
J Clin Invest. 1998 Aug 15;102(4):792-803. doi: 10.1172/JCI3201.
3
Majority of gliadin-specific T-cell clones from celiac small intestinal mucosa produce interferon-gamma and interleukin-4.来自乳糜泻小肠黏膜的大多数麦醇溶蛋白特异性T细胞克隆产生γ干扰素和白细胞介素-4。
Dig Dis Sci. 1998 Jan;43(1):156-61. doi: 10.1023/a:1018896625699.
4
Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing.肠道上皮细胞利用两种不同的途径进行HLA II类抗原加工。
J Clin Invest. 1997 Jul 1;100(1):204-15. doi: 10.1172/JCI119514.
5
Translocation of gliadin into HLA-DR antigen containing lysosomes in coeliac disease enterocytes.麸质转位至乳糜泻肠细胞中含有HLA - DR抗原的溶酶体。
Gut. 1995 May;36(5):703-9. doi: 10.1136/gut.36.5.703.
6
Effect of gliadin and other food peptides on expression of MHC class II molecules by HT-29 cells.麦醇溶蛋白和其他食物肽对HT-29细胞MHC II类分子表达的影响。
Gut. 1995 Apr;36(4):548-52. doi: 10.1136/gut.36.4.548.
7
Sequential induction of MHC antigens on autochthonous cells of ileum affected by Crohn's disease.克罗恩病累及的回肠自身细胞上MHC抗原的序贯诱导
Am J Pathol. 1987 Dec;129(3):493-502.
8
HLA-DR, DP and DQ expression in the small intestine of patients with coeliac disease.乳糜泻患者小肠中HLA - DR、DP和DQ的表达
Clin Exp Immunol. 1987 Nov;70(2):386-93.
9
HLA-DR expression, natural killer cells and IgE containing cells in the jejunal mucosa of coeliac children.乳糜泻患儿空肠黏膜中的人类白细胞抗原-DR表达、自然杀伤细胞及含免疫球蛋白E的细胞
Gut. 1987 Aug;28(8):988-94. doi: 10.1136/gut.28.8.988.
10
Immunoperoxidase demonstration of the cellular composition of the normal and coeliac small bowel.免疫过氧化物酶法显示正常及乳糜泻小肠的细胞组成。
Clin Exp Immunol. 1987 Apr;68(1):177-88.

本文引用的文献

1
Immunohistochemical techniques in the early screening of monoclonal antibodies to human colonic epithelium.免疫组织化学技术在人结肠上皮单克隆抗体早期筛查中的应用
Br J Cancer. 1982 Jul;46(1):9-17. doi: 10.1038/bjc.1982.158.
2
HLA-DR-like antigens in the epithelium of the human small intestine.人类小肠上皮中的HLA - DR样抗原。
Scand J Immunol. 1980;12(1):77-82. doi: 10.1111/j.1365-3083.1980.tb00043.x.
3
Clinical testing of gliadin fractions in coeliac patients.乳糜泻患者中麦醇溶蛋白组分的临床试验。
Clin Sci (Lond). 1984 Mar;66(3):357-64. doi: 10.1042/cs0660357.
4
Expression of HLA-DR (Ia like) antigen on epidermal keratinocytes in human dermatoses.人皮肤病中表皮角质形成细胞上HLA - DR（类Ia）抗原的表达。
Clin Exp Immunol. 1984 Jul;57(1):93-100.
5
Clinical testing of bread made from nullisomic 6A wheats in coeliac patients.对乳糜泻患者使用6A缺体小麦制成的面包进行临床试验。
Lancet. 1980 Aug 2;2(8188):234-6. doi: 10.1016/s0140-6736(80)90123-3.
6
Human lymphocyte antigens: a mini review.人类淋巴细胞抗原：一篇综述短文
Biochem Soc Trans. 1985 Apr;13(2):429-32. doi: 10.1042/bst0130429a.

麸质对乳糜泻患者小肠上皮中HLA - DR的影响。

The effect of gluten on HLA-DR in the small intestinal epithelium of patients with coeliac disease.

作者信息

Ciclitira P J, Nelufer J M, Ellis H J, Evans D J

出版信息

Clin Exp Immunol. 1986 Jan;63(1):101-4.

PMID:3514010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1577323/
Abstract

Frozen sections of control and coeliac jejunal mucosa were examined for HLA-DR staining. In general the staining pattern in the controls and treated coeliac patients was a patchy subapical pattern on villous tips. Untreated coeliac patients gave a different pattern with staining extending to the crypt enterocytes. Gluten challenge in three treated coeliac patients induced an altered staining pattern within 2 h.

摘要

对对照和乳糜泻空肠黏膜的冰冻切片进行HLA - DR染色检查。总体而言，对照组和接受治疗的乳糜泻患者的染色模式为绒毛尖端的斑片状顶端下模式。未经治疗的乳糜泻患者呈现出不同的模式，染色延伸至隐窝肠上皮细胞。三名接受治疗的乳糜泻患者在麸质激发后2小时内染色模式发生改变。