Tzipori S, Montanaro J, Robins-Browne R M, Vial P, Gibson R, Levine M M
Department of Microbiology, Royal Children's Hospital, Melbourne, Australia.
Infect Immun. 1992 Dec;60(12):5302-6. doi: 10.1128/iai.60.12.5302-5306.1992.
Two strains of enteroaggregative Escherichia coli of human origin fed to gnotobiotic piglets caused diarrhea or death in the majority of them. Histological examination revealed moderate hyperemia of the distal small intestine and cecum, swelling of small intestinal villi, and layers of aggregated bacteria stacked together in a mucus gel-like matrix overlying intact epithelium. These findings confirm that enteroaggregative E. coli strains produce distinctive intestinal lesions different from those caused by other major categories of diarrheagenic E. coli.
给无菌仔猪投喂两株源自人类的肠集聚性大肠杆菌，多数仔猪出现腹泻或死亡。组织学检查显示，远端小肠和盲肠中度充血，小肠绒毛肿胀，完整上皮表面有一层细菌在黏液凝胶样基质中聚集在一起。这些发现证实，肠集聚性大肠杆菌菌株会产生与其他主要致泻性大肠杆菌类别所引起的病变不同的独特肠道病变。
