Mathewson J J, Johnson P C, DuPont H L, Morgan D R, Thornton S A, Wood L V, Ericsson C D
J Infect Dis. 1985 Mar;151(3):471-5. doi: 10.1093/infdis/151.3.471.
Adherence to HEp-2 tissue culture cells has been proposed as a virulence characteristic of enteropathogenic Escherichia coli (EPEC). A preliminary study revealed that E. coli that adhered to HEp-2 cells, but did not produce conventional enterotoxins and did not belong to recognized EPEC serogroups, could be isolated from adults from the United States who acquired diarrhea in Mexico. The purpose of this study was to determine the prevalence of these enteroadherent E. coli (EAEC) in 188 travelers with diarrhea and in 92 well travelers. EAEC were found in 14.9% of patients with diarrhea and in 7.6% of well individuals. Compared with well travelers, patients with diarrhea in whom no recognized enteropathogen could be identified had a 30.4% prevalence of EAEC (P less than .0003). These results further support our finding that EAEC are associated with diarrhea in travelers to Mexico and may help to explain the effect of antibiotics in the prevention and therapy for travelers' diarrhea in patients with no recognized bacterial enteropathogens.
黏附于HEp - 2组织培养细胞已被认为是肠致病性大肠杆菌（EPEC）的一种毒力特征。一项初步研究显示，从在墨西哥患腹泻的美国成年人中可分离出黏附于HEp - 2细胞，但不产生传统肠毒素且不属于公认EPEC血清群的大肠杆菌。本研究的目的是确定188例腹泻旅行者和92例健康旅行者中这些肠黏附性大肠杆菌（EAEC）的患病率。腹泻患者中EAEC的检出率为14.9%，健康个体中为7.6%。与健康旅行者相比，未发现公认肠道病原体的腹泻患者中EAEC的患病率为30.4%（P小于0.0003）。这些结果进一步支持了我们的发现，即EAEC与前往墨西哥的旅行者腹泻有关，并且可能有助于解释抗生素在预防和治疗无公认细菌性肠道病原体的旅行者腹泻中的作用。
