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一种针对百日咳博德特氏菌脂寡糖的杀菌性单克隆抗体，可降低小鼠经气溶胶感染百日咳博德特氏菌后呼吸道的定植。

A bactericidal monoclonal antibody specific for the lipooligosaccharide of Bordetella pertussis reduces colonization of the respiratory tract of mice after aerosol infection with B. pertussis.

作者信息

Mountzouros K T, Kimura A, Cowell J L

机构信息

Praxis Biologics, Inc., Rochester, New York 14623.

出版信息

Infect Immun. 1992 Dec;60(12):5316-8. doi: 10.1128/iai.60.12.5316-5318.1992.

DOI:10.1128/iai.60.12.5316-5318.1992
PMID:1452367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC258314/
Abstract

A mouse immunoglobulin G3 monoclonal antibody specific for the core oligosaccharide moiety of the lipooligosaccharide (LOS) of Bordetella pertussis has been shown to have complement-dependent bactericidal activity. This monoclonal antibody exhibits bactericidal activity against strains of B. pertussis that express the LOS A phenotype. In addition this monoclonal antibody was effective in reducing colonization by B. pertussis in both the lungs and tracheas of mice after aerosol infection.

摘要

一种针对百日咳博德特氏菌脂寡糖（LOS）核心寡糖部分的小鼠免疫球蛋白G3单克隆抗体已被证明具有补体依赖性杀菌活性。这种单克隆抗体对表达LOS A表型的百日咳博德特氏菌菌株具有杀菌活性。此外，在气溶胶感染后，这种单克隆抗体能有效减少小鼠肺部和气管中百日咳博德特氏菌的定植。

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A bactericidal monoclonal antibody specific for the lipooligosaccharide of Bordetella pertussis reduces colonization of the respiratory tract of mice after aerosol infection with B. pertussis.一种针对百日咳博德特氏菌脂寡糖的杀菌性单克隆抗体，可降低小鼠经气溶胶感染百日咳博德特氏菌后呼吸道的定植。
Infect Immun. 1992 Dec;60(12):5316-8. doi: 10.1128/iai.60.12.5316-5318.1992.
2
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本文引用的文献

1
Two physically and serologically distinct lipopolysaccharide profiles in strains of Bordetella pertussis and their phenotype variants.百日咳博德特氏菌菌株及其表型变体中的两种在物理和血清学上不同的脂多糖谱。
Infect Immun. 1984 Jan;43(1):224-32. doi: 10.1128/iai.43.1.224-232.1984.
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Isolation of two protein-free and chemically different lipopolysaccharides from Bordetella pertussis phenol-extracted endotoxin.从百日咳博德特氏菌酚提取内毒素中分离出两种无蛋白质且化学性质不同的脂多糖。
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Aerosol infection of mice with Bordetella pertussis.用百日咳博德特氏菌对小鼠进行气溶胶感染。
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Structure of the terminal reducing heptasaccharide of polysaccharide 1 isolated from the Bordetella pertussis endotoxin.从百日咳博德特氏菌内毒素中分离出的多糖1末端还原七糖的结构。
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The antigen of Bordetella pertussis that induces bactericidal antibody and its relationship to protection of mice.百日咳博德特氏菌诱导杀菌抗体的抗原及其与小鼠保护作用的关系。
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Agglutinating monoclonal antibodies that specifically recognize lipooligosaccharide A of Bordetella pertussis.能特异性识别百日咳博德特氏菌脂寡糖A的凝集性单克隆抗体。
Infect Immun. 1988 Mar;56(3):699-702. doi: 10.1128/iai.56.3.699-702.1988.
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Variations in the carbohydrate regions of Bordetella pertussis lipopolysaccharides: electrophoretic, serological, and structural features.百日咳博德特氏菌脂多糖碳水化合物区域的变异：电泳、血清学及结构特征
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Bordetella pertussis filamentous hemagglutinin: evaluation as a protective antigen and colonization factor in a mouse respiratory infection model.百日咳博德特氏菌丝状血凝素：在小鼠呼吸道感染模型中作为保护性抗原和定植因子的评估
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Biological properties of lipopolysaccharides from Bordetella species.
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A protective human monoclonal antibody directed to the outer core region of Pseudomonas aeruginosa lipopolysaccharide.一种针对铜绿假单胞菌脂多糖外核心区域的保护性人源单克隆抗体。
Infect Immun. 1991 Jan;59(1):1-6. doi: 10.1128/iai.59.1.1-6.1991.