一种针对百日咳博德特氏菌脂寡糖的杀菌性单克隆抗体，可降低小鼠经气溶胶感染百日咳博德特氏菌后呼吸道的定植。
A bactericidal monoclonal antibody specific for the lipooligosaccharide of Bordetella pertussis reduces colonization of the respiratory tract of mice after aerosol infection with B. pertussis.
作者信息
Mountzouros K T, Kimura A, Cowell J L
机构信息
Praxis Biologics, Inc., Rochester, New York 14623.
出版信息
Infect Immun. 1992 Dec;60(12):5316-8. doi: 10.1128/iai.60.12.5316-5318.1992.
Abstract
A mouse immunoglobulin G3 monoclonal antibody specific for the core oligosaccharide moiety of the lipooligosaccharide (LOS) of Bordetella pertussis has been shown to have complement-dependent bactericidal activity. This monoclonal antibody exhibits bactericidal activity against strains of B. pertussis that express the LOS A phenotype. In addition this monoclonal antibody was effective in reducing colonization by B. pertussis in both the lungs and tracheas of mice after aerosol infection.
摘要
一种针对百日咳博德特氏菌脂寡糖（LOS）核心寡糖部分的小鼠免疫球蛋白G3单克隆抗体已被证明具有补体依赖性杀菌活性。这种单克隆抗体对表达LOS A表型的百日咳博德特氏菌菌株具有杀菌活性。此外，在气溶胶感染后，这种单克隆抗体能有效减少小鼠肺部和气管中百日咳博德特氏菌的定植。
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A bactericidal monoclonal antibody specific for the lipooligosaccharide of Bordetella pertussis reduces colonization of the respiratory tract of mice after aerosol infection with B. pertussis.一种针对百日咳博德特氏菌脂寡糖的杀菌性单克隆抗体，可降低小鼠经气溶胶感染百日咳博德特氏菌后呼吸道的定植。
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Two physically and serologically distinct lipopolysaccharide profiles in strains of Bordetella pertussis and their phenotype variants.百日咳博德特氏菌菌株及其表型变体中的两种在物理和血清学上不同的脂多糖谱。
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