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能特异性识别百日咳博德特氏菌脂寡糖A的凝集性单克隆抗体。

Agglutinating monoclonal antibodies that specifically recognize lipooligosaccharide A of Bordetella pertussis.

作者信息

Li Z M, Cowell J L, Brennan M J, Burns D L, Manclark C R

机构信息

Division of Bacterial Products, Food and Drug Administration, Bethesda, Maryland 20892.

出版信息

Infect Immun. 1988 Mar;56(3):699-702. doi: 10.1128/iai.56.3.699-702.1988.

DOI:10.1128/iai.56.3.699-702.1988
PMID:2893776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC259348/
Abstract

Monoclonal antibodies that specifically agglutinate strains of Bordetella pertussis having serotype 1 agglutinogen were uniquely reactive with the electrophoretically slow-migrating A form of lipooligosaccharide. These monoclonal antibodies should be useful for the structural analysis of B. pertussis lipooligosaccharide and for the establishment of a better-defined serogroup for Bordetella species.

摘要

能特异性凝集具有1型凝集原血清型的百日咳博德特氏菌菌株的单克隆抗体，与脂寡糖电泳迁移缓慢的A形式具有独特的反应性。这些单克隆抗体应有助于百日咳博德特氏菌脂寡糖的结构分析，以及为博德特氏菌属建立更明确的血清群。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/259348/fc641d36a63d/iai00075-0173-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/259348/a01eb4bfcdf0/iai00075-0172-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/259348/7dbe31b648f5/iai00075-0172-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/259348/75d7d8ae8d7b/iai00075-0173-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/259348/c04b3b978c05/iai00075-0173-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/259348/fc641d36a63d/iai00075-0173-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/259348/a01eb4bfcdf0/iai00075-0172-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/259348/7dbe31b648f5/iai00075-0172-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/259348/75d7d8ae8d7b/iai00075-0173-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/259348/c04b3b978c05/iai00075-0173-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4b5/259348/fc641d36a63d/iai00075-0173-c.jpg

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本文引用的文献

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Serological study of Bordetella pertussis and related species.百日咳博德特氏菌及相关菌种的血清学研究
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Production of monoclonal antibodies: strategy and tactics.单克隆抗体的制备：策略与战术
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Heterogeneity of molecular size and antigenic expression within lipooligosaccharides of individual strains of Neisseria gonorrhoeae and Neisseria meningitidis.淋病奈瑟菌和脑膜炎奈瑟菌各菌株脂寡糖内分子大小和抗原表达的异质性。
用于鉴定百日咳博德特氏菌的快速免疫斑点技术。
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Analysis of protective and nonprotective monoclonal antibodies specific for Bordetella pertussis lipooligosaccharide.针对百日咳博德特氏菌脂寡糖的保护性和非保护性单克隆抗体分析。
Infect Immun. 1994 Feb;62(2):722-5. doi: 10.1128/iai.62.2.722-725.1994.
5
Antigenic analysis of the saccharide moiety of the lipooligosaccharide of Bordetella pertussis.百日咳博德特氏菌脂寡糖糖部分的抗原分析。
Springer Semin Immunopathol. 1993;15(2-3):205-15. doi: 10.1007/BF00201101.
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Isotype and antigen specificity of pertussis agglutinins following whole-cell pertussis vaccination and infection with Bordetella pertussis.全细胞百日咳疫苗接种及感染百日咳博德特氏菌后百日咳凝集素的同种型和抗原特异性
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Identification of a 69-kilodalton nonfimbrial protein as an agglutinogen of Bordetella pertussis.鉴定一种69千道尔顿的非菌毛蛋白作为百日咳博德特氏菌的一种凝集原。
Infect Immun. 1988 Dec;56(12):3189-95. doi: 10.1128/iai.56.12.3189-3195.1988.
8
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Infect Immun. 1988 Dec;56(12):3184-8. doi: 10.1128/iai.56.12.3184-3188.1988.
9
Lethal infection by Bordetella pertussis mutants in the infant mouse model.百日咳博德特氏菌突变体在幼鼠模型中的致死性感染
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10
Use of the promoter fusion transposon Tn5 lac to identify mutations in Bordetella pertussis vir-regulated genes.利用启动子融合转座子Tn5 lac鉴定百日咳博德特氏菌毒力调节基因中的突变。
Infect Immun. 1989 Sep;57(9):2674-82. doi: 10.1128/iai.57.9.2674-2682.1989.
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Heterogeneity and variation among Neisseria meningitidis lipopolysaccharides.脑膜炎奈瑟菌脂多糖的异质性与变异性。
J Bacteriol. 1983 Aug;155(2):498-504. doi: 10.1128/jb.155.2.498-504.1983.
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Two physically and serologically distinct lipopolysaccharide profiles in strains of Bordetella pertussis and their phenotype variants.百日咳博德特氏菌菌株及其表型变体中的两种在物理和血清学上不同的脂多糖谱。
Infect Immun. 1984 Jan;43(1):224-32. doi: 10.1128/iai.43.1.224-232.1984.
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Isolation of two protein-free and chemically different lipopolysaccharides from Bordetella pertussis phenol-extracted endotoxin.从百日咳博德特氏菌酚提取内毒素中分离出两种无蛋白质且化学性质不同的脂多糖。
J Bacteriol. 1980 Jul;143(1):78-88. doi: 10.1128/jb.143.1.78-88.1980.
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A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels.一种用于检测聚丙烯酰胺凝胶中脂多糖的灵敏银染法。
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Detection and localization of a lectin on Actinomyces viscosus T14V by monoclonal antibodies.利用单克隆抗体检测和定位粘性放线菌T14V上的一种凝集素。
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9
Structure of the terminal reducing heptasaccharide of polysaccharide 1 isolated from the Bordetella pertussis endotoxin.从百日咳博德特氏菌内毒素中分离出的多糖1末端还原七糖的结构。
J Bacteriol. 1984 Aug;159(2):611-7. doi: 10.1128/jb.159.2.611-617.1984.
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A method for purification of bacterial R-type lipopolysaccharides (lipooligosaccharides).一种纯化细菌R型脂多糖（脂寡糖）的方法。
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