从百日咳博德特氏菌内毒素中分离出的多糖1末端还原七糖的结构。
Structure of the terminal reducing heptasaccharide of polysaccharide 1 isolated from the Bordetella pertussis endotoxin.
作者信息
Moreau M, Chaby R, Szabo L
出版信息
J Bacteriol. 1984 Aug;159(2):611-7. doi: 10.1128/jb.159.2.611-617.1984.
Abstract
The tetrasaccharide beta-D-glucopyranosyl-(1,3)-beta-D-glucopyranuronyl-(1, 2)-L-glycero-alpha-D-manno-heptopyranosyl-(1,5)-3-deoxy-D-manno-2- octulosonic acid was isolated after treatment of polysaccharide 1 of Bordetella pertussis endotoxin with nitrous acid. Taking into account previously identified di- and trisaccharide fragments and analytical data obtained for the intact polysaccharide 1, we present the structure of a heptasaccharide that is thought to represent the region immediately adjacent to the hydrophobic (lipid A) moiety of lipopolysaccharide 1 of the B. pertussis endotoxin. This heptasaccharide represents 50 to 60% of the complete polysaccharide structure.
摘要
用亚硝酸处理百日咳博德特氏菌内毒素的多糖1后，分离出四糖β-D-吡喃葡萄糖基-(1,3)-β-D-吡喃葡萄糖醛酸基-(1, 2)-L-甘油-α-D-甘露庚糖基-(1,5)-3-脱氧-D-甘露-2-辛酮糖酸。考虑到先前鉴定的二糖和三糖片段以及完整多糖1获得的分析数据，我们提出了一种七糖的结构，该结构被认为代表了百日咳博德特氏菌内毒素脂多糖1的疏水（脂质A）部分紧邻的区域。这种七糖占完整多糖结构的50%至60%。
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