Chen Jack J, Swope David M
Department of Pharmacy Practice, College of Pharmacy, Western University of Health Sciences, Pomona, California 91766-1854, USA.
Pharmacotherapy. 2003 Sep;23(9):1105-22. doi: 10.1592/phco.23.10.1105.32750.
Essential tremor is a common movement disorder in adults that interferes with the performance of functional and social activities. Differentiation of essential tremor from other tremor syndromes is important in order to provide appropriate patient education and therapy. The mainstays of pharmacotherapy are propranolol and primidone; however, in selected patients, agents such as alcohol, benzodiazepines, botulinum toxin, and gabapentin may provide symptomatic benefits. Advances in surgical interventions, such as stereotactic thalamotomy and thalamic deep brain stimulation, offer patients an alternative treatment modality when pharmacotherapy is inadequate. A treatment algorithm is provided to guide clinicians in the management of patients with essential tremor.
特发性震颤是成人常见的运动障碍，会干扰功能性和社交活动的表现。为了提供适当的患者教育和治疗，将特发性震颤与其他震颤综合征区分开来很重要。药物治疗的主要药物是普萘洛尔和扑米酮；然而，在特定患者中，酒精、苯二氮䓬类药物、肉毒杆菌毒素和加巴喷丁等药物可能会带来症状改善。立体定向丘脑切开术和丘脑深部脑刺激等手术干预的进展，为药物治疗不足的患者提供了另一种治疗方式。提供了一种治疗算法，以指导临床医生管理特发性震颤患者。
