Rupp M E, Soper D E, Archer G L
Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
J Clin Microbiol. 1992 Nov;30(11):2975-9. doi: 10.1128/jcm.30.11.2975-2979.1992.
The prevalence of colonization by Staphylococcus saprophyticus of the urogenital tracts of 276 women from an outpatient gynecology practice was determined by using selective and enrichment culture techniques. Nineteen subjects (6.9%) were found to be colonized by S. saprophyticus. The rectum was the most frequent site of colonization and was responsible for 40% of the isolates; this was followed in decreasing order by the urethra, urine, and cervix. Women colonized by S. saprophyticus were more likely to have experienced a urinary tract infection in the previous 12 months (P = 0.058; odds ratio, 2.844; 95% confidence interval, 1.054 to 7.671). Patients colonized by S. saprophyticus tended to have had their menstrual periods more recently (P = 0.066), experienced sexual intercourse more recently (P = 0.168), and had a recent or concurrent diagnosis of vaginal candidiasis (P = 0.111; odds ratio, 2.393; 95% confidence interval, 0.877 to 6.528). A seasonal variation in colonization was observed, with colonization most likely occurring during the summer and fall. Follow-up for an average of 6.75 months failed to document any colonized woman progressing to symptomatic urinary tract infection. In addition, 21 women colonized by non-S. saprophyticus, novobiocin-resistant, coagulase-negative staphylococci were identified and characterized.
采用选择性和增菌培养技术，对来自门诊妇科的276名女性泌尿生殖道腐生葡萄球菌的定植率进行了测定。发现19名受试者（6.9%）被腐生葡萄球菌定植。直肠是最常见的定植部位，占分离株的40%；其次依次是尿道、尿液和宫颈。在过去12个月中，被腐生葡萄球菌定植的女性更有可能发生过尿路感染（P = 0.058；比值比，2.844；95%置信区间，1.054至7.671）。被腐生葡萄球菌定植的患者月经来潮时间往往更近（P = 0.066），最近有过性行为（P = 0.168），并且最近或同时被诊断为阴道念珠菌病（P = 0.111；比值比，2.393；95%置信区间，0.877至6.528）。观察到定植存在季节性变化，最有可能在夏季和秋季发生定植。平均随访6.75个月，未发现任何定植女性进展为有症状的尿路感染。此外，还鉴定并描述了21名被非腐生葡萄球菌、耐新生霉素、凝固酶阴性葡萄球菌定植的女性。
