Barrère F, van der Valk C M, Meijer G, Dalmeijer R A J, de Groot K, Layrolle P
IsoTis, PO Box 98, 3720 AB, Bilthoven, The Netherlands.
J Biomed Mater Res B Appl Biomater. 2003 Oct 15;67(1):655-65. doi: 10.1002/jbm.b.10057.
Biomimetic calcium phosphate (Ca-P) coatings were applied onto dense titanium alloy (Ti6Al4V) and porous tantalum (Ta) cylinders by immersion into simulated body fluid at 37 degrees C and then at 50 degrees C for 24 h. As a result, a homogeneous bone-like carbonated apatitic (BCA) coating, 30 microm thick was deposited on the entire surface of the dense and porous implants. Noncoated and BCA-coated implants were press-fit implanted in the femoral diaphysis of 14 adult female goats. Bone contact was measured after implantation for 6, 12, and 24 weeks, and investigated by histology and backscattered electron microscopy (BSEM). After 6 weeks, bone contact of the BCA-coated Ti6Al4V implants was about 50%. After 12 and 24 weeks, bone contact was lower in comparison with the 6-week implantations at, respectively 24 and 39%. Regarding the BCA-coated porous Ta implants, bone contacts were 17, 30, and 18% after 6, 12, and 24 weeks, respectively. However, bone contact was always found significantly higher for BCA-coated dense Ti6Al4V and porous Ta cylinders than the corresponding noncoated implants. The results of this study show that the BCA coating enhances the bone integration as compared to the noncoated implants.
通过在37℃的模拟体液中浸泡，然后在50℃下浸泡24小时，将仿生磷酸钙（Ca-P）涂层施加到致密钛合金（Ti6Al4V）和多孔钽（Ta）圆柱体上。结果，在致密和多孔植入物的整个表面上沉积了一层30微米厚的均匀骨状碳酸磷灰石（BCA）涂层。将未涂层和BCA涂层的植入物压配合植入14只成年雌性山羊的股骨干中。在植入6、12和24周后测量骨接触情况，并通过组织学和背散射电子显微镜（BSEM）进行研究。6周后，BCA涂层的Ti6Al4V植入物的骨接触率约为50%。12周和24周后，与6周植入时相比，骨接触率分别降低至24%和39%。对于BCA涂层的多孔Ta植入物，6周、12周和24周后的骨接触率分别为17%、30%和18%。然而，始终发现BCA涂层的致密Ti6Al4V和多孔Ta圆柱体的骨接触率明显高于相应的未涂层植入物。这项研究的结果表明，与未涂层的植入物相比，BCA涂层增强了骨整合。
