Dholabhai Pratesh, Thakur Surabhi, Sharma Deepak, Sathish Narendra, Kar Sunil, Gupta Sameer
Department of Oral and Maxillofacial Surgery, K.M Shah Dental College and Hospital, Sumandeep Vidyapeeth Deemed to be University, Gujarat, India.
Department of Prosthodontics and Crown & Bridge, Seema dental college and hospital, Rishikesh, Uttarakhand, India.
Bioinformation. 2025 Feb 28;21(2):161-164. doi: 10.6026/973206300210161. eCollection 2025.
The success of dental implants depends on osseo-integration because titanium (Ti) maintains good mechanical stability while zirconia (Zr) prevents bacterial adhesion. The early-stage adhesion of MG-63 osteo-blast-like cells to Ti surfaces reached 78% ± 2.5% during the initial period (p<0.05). However, Zr demonstrated superior long-term cell proliferation and mineralization throughout the analysis period (p<0.05). The alkaline phosphatase (ALP) levels at day 7 remained comparable between Ti (1.25 ± 0.09 U/mL) and Zr (1.18 ± 0.07 U/mL) while Zr showed better growth of mineralized surface at day 14. Nonetheless, additional testing using animal subjects are required to confirm Zr as a suitable substitute for Ti implants.
种植牙的成功取决于骨结合，因为钛（Ti）能保持良好的机械稳定性，而氧化锆（Zr）可防止细菌黏附。在初始阶段，MG-63成骨样细胞与钛表面的早期黏附率在最初阶段达到78%±2.5%（p<0.05）。然而，在整个分析期内，氧化锆显示出卓越的长期细胞增殖和矿化能力（p<0.05）。第7天时，钛（1.25±0.09 U/mL）和氧化锆（1.18±0.07 U/mL）的碱性磷酸酶（ALP）水平相当，而在第14天时，氧化锆显示出更好的矿化表面生长情况。尽管如此，仍需要使用动物受试者进行额外测试，以确认氧化锆作为钛植入物的合适替代品。
