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使用GAFCHROMIC薄膜进行高精度薄膜剂量测定以进行质量保证,特别是在使用小射野时。

High precision film dosimetry with GAFCHROMIC films for quality assurance especially when using small fields.

作者信息

Mack Andreas, Mack Günther, Weltz Dirk, Scheib Stefan G, Böttcher Heinz D, Seifert Volker

机构信息

Gamma Knife Center, Schleusenweg 2-16, NG 95, 60528 Frankfurt, Germany.

出版信息

Med Phys. 2003 Sep;30(9):2399-409. doi: 10.1118/1.1593634.

Abstract

Treatment units for radiosurgery, brachytherapy, implementation of seeds, and IMRT generate small high dose regions together with steep dose gradients of up to 30%-50% per mm. Such devices are used to treat small complex-shaped lesions, often located close to critical structures, by superimposing several single high dose regions. In order to test and verify these treatment techniques, to perform quality assurance tasks and to simulate treatment conditions as well as to collect input data for treatment planning, a GAFCHROMIC film based dosimetry system for measuring two-dimensional (2-D) and three-dimensional (3-D) dose distributions was developed. The nearly tissue-equivalent radiochromic GAFCHROMIC film was used to measure dose distributions. A drum scanner was investigated and modified. The spectral emission of the light source and the filters together with the efficiency of the CCD filters for the red color were matched and balanced with the absorption spectra of the film. Models based on refined studies have been developed to characterize theoretically the physics of film exposure and to calibrate the film. Mathematical descriptions are given to calculate optical densities from spectral data. The effect of darkening has been investigated and is described with a mathematical model. The influence of the scan temperature has been observed and described. In order to cope with the problem of individual film inhomogeneities, a double irradiation technique is introduced and implemented that yields dose accuracies as good as 2%-3%. Special software routines have been implemented for evaluating and handling the film data.

摘要

用于放射外科、近距离放射治疗、粒子植入以及调强放射治疗的治疗设备会产生小的高剂量区域,同时伴有高达每毫米30%-50%的陡峭剂量梯度。这类设备通过叠加多个单个高剂量区域来治疗通常位于关键结构附近的小的复杂形状病变。为了测试和验证这些治疗技术、执行质量保证任务、模拟治疗条件以及收集治疗计划的输入数据,开发了一种基于GAFCHROMIC膜的剂量测定系统,用于测量二维(2-D)和三维(3-D)剂量分布。使用近乎组织等效的放射变色GAFCHROMIC膜来测量剂量分布。对鼓式扫描仪进行了研究和改进。将光源和滤光片的光谱发射以及用于红色的电荷耦合器件(CCD)滤光片的效率与膜的吸收光谱进行匹配和平衡。基于精细研究开发了模型,从理论上表征膜曝光的物理过程并对膜进行校准。给出了从光谱数据计算光密度的数学描述。研究了暗化效应并用数学模型进行了描述。观察并描述了扫描温度的影响。为了解决单个膜不均匀性的问题,引入并实施了双照射技术,其剂量精度可达2%-3%。已实施特殊的软件程序来评估和处理膜数据。

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