Dietrich G, Sperling S, Hetzer G
Department of Paediatric Dentistry, University of Technology, Dresden, Germany.
Eur J Paediatr Dent. 2003 Sep;4(3):133-7.
This was to determine the prevalence of Molar Incisor Hypomineralisation (MIH) and to evaluate possible causes of these enamel defects.
The study group consisted of 2,408 10-17 year old children born during 1985-1992 and living in Dresden (Germany). Enamel defects were recorded using the modified DDE index. Children with enamel defects and their parents were invited for a re-examination to record the medical history of the children during the first 3 years of life; these children were matched by age with other children with apparently normal first molars (control group).
135 (5.6%) of the children had demarcated opacities in at least one first molar, i.e. MIH. A significantly higher prevalence of MIH was seen in children born between 1989 and 1991 compared with those born before and after that period (p<0.01). The number of children returning for the medical history questionnaire was low, 31 out of 135 responded (test group). Although there were no significant differences between the test and control groups in terms of peri and neonatal complications or other health problems, the low return precluded any definitive interpretation.
The overall prevalence of MIH in this study was low by comparison with other previous epidemiological reports.
本研究旨在确定磨牙切牙矿化不全（MIH）的患病率，并评估这些釉质缺陷的可能原因。
研究组由1985年至1992年期间出生且居住在德累斯顿（德国）的2408名10至17岁儿童组成。使用改良的DDE指数记录釉质缺陷情况。患有釉质缺陷的儿童及其父母被邀请再次接受检查，以记录儿童出生后头3年的病史；这些儿童按年龄与其他第一恒磨牙明显正常的儿童（对照组）进行匹配。
135名（5.6%）儿童至少有一颗第一恒磨牙出现界限清晰的釉质混浊，即MIH。与该时期之前和之后出生的儿童相比，1989年至1991年期间出生的儿童MIH患病率显著更高（p<0.01）。返回填写病史问卷的儿童数量较少，135名中有31名回复（试验组）。尽管试验组和对照组在围产期和新生儿并发症或其他健康问题方面没有显著差异，但回复率低使得无法做出任何确切的解释。
与之前的其他流行病学报告相比，本研究中MIH的总体患病率较低。
