[溃疡性结肠炎中的乳糖吸收不良。一项病例对照研究]
[Lactose malabsorption in ulcerative colitis. A case-control study].
作者信息
Ginard D, Riera J, Bonet L, Barranco L, Reyes J, Escarda A, Obrador A
机构信息
Servicio de Aparato Digestivo. Hospital Son Dureta. Palma de Mallorca. Spain.
出版信息
Gastroenterol Hepatol. 2003 Oct;26(8):469-74. doi: 10.1016/s0210-5705(03)70396-3.
BACKGROUND
The role of lactose malabsorption in ulcerative colitis is controversial. The aim of this study was to compare the prevalence of lactose malabsorption in a group of ulcerative colitis patients and a control group and to modify lactose consumption in view of the results.
METHODS
Lactose malabsorption was studied using the hydrogen breath test in 52 patients with ulcerative colitis and 34 controls after ingestion of 25 g of lactose. A questionnaire on ingestion of milk products was also administered.
RESULTS
Of the 52 patients with ulcerative colitis, 13 (25%) presented lactose malabsorption compared with 11 of the 34 (32%) controls (p = 0.45). Twenty-four patients (46%) had been advised to completely eliminate lactose from their diets. Twenty-seven of the 39 patients without malabsorption had reduced or eliminated lactose consumption after being diagnosed with ulcerative colitis.
CONCLUSIONS
No significant differences in the prevalence of lactose malabsorption was found between patients with ulcerative colitis and controls. We believe that systematic elimination of lactose from the diets of these patients is erroneous. In our environment, we recommend the hydrogen breath test only in patients with symptoms of lactose intolerance.
背景
乳糖吸收不良在溃疡性结肠炎中的作用存在争议。本研究旨在比较一组溃疡性结肠炎患者和对照组中乳糖吸收不良的患病率，并根据结果调整乳糖摄入量。
方法
对52例溃疡性结肠炎患者和34例对照者在摄入25克乳糖后采用氢呼气试验研究乳糖吸收不良情况。同时还发放了一份关于奶制品摄入情况的问卷。
结果
52例溃疡性结肠炎患者中，13例（25%）存在乳糖吸收不良，而34例对照者中有11例（32%）存在乳糖吸收不良（p = 0.45）。24例患者（46%）曾被建议完全从饮食中消除乳糖。在39例无吸收不良的患者中，27例在被诊断为溃疡性结肠炎后减少或消除了乳糖摄入。
结论
溃疡性结肠炎患者和对照组之间乳糖吸收不良的患病率无显著差异。我们认为，对这些患者的饮食进行系统性乳糖消除是错误的。在我们的环境中，我们建议仅对有乳糖不耐受症状的患者进行氢呼气试验。
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