Sciarretta G, Giacobazzi G, Verri A, Zanirato P, Garuti G, Malaguti P
Dig Dis Sci. 1984 Dec;29(12):1098-104. doi: 10.1007/BF01317083.
Lactose malabsorption was studied, by hydrogen breath test, in 72 adults suffering from irritable bowel syndrome, in 20 ulcerative colitis patients, and in 69 healthy subjects. The minimum dose of lactose required to cause a positive breath test was determined, and the symptoms caused and the resulting hydrogen eliminated quantified. A high incidence of lactose malabsorption was shown at standard doses (up to 50 g) in both the healthy subjects (70%) and the patients (86% and 85%, respectively). In the irritable bowel syndrome and the ulcerative colitis groups, symptoms occurred with a smaller quantity of breath hydrogen, presumably in association with a greater individual sensitivity of the colon to distension. The threshold lactose dose was notably lower in the diseased subjects who registered as evidence a prevalence of malabsorption at a 20-g lactose load. The pathogenetic role of lactose malabsorption in the irritable bowel syndrome is emphasized, as is the importance of the personal lactose tolerance.
通过氢呼气试验，对72名患有肠易激综合征的成年人、20名溃疡性结肠炎患者和69名健康受试者进行了乳糖吸收不良的研究。确定了引起呼气试验呈阳性所需的最低乳糖剂量，并对所引起的症状以及产生的氢气排出量进行了量化。在健康受试者（70%）和患者（分别为86%和85%）中，标准剂量（高达50克）下乳糖吸收不良的发生率很高。在肠易激综合征和溃疡性结肠炎组中，出现症状时呼出的氢气量较少，推测这与结肠对扩张的个体敏感性较高有关。在乳糖负荷为20克时显示吸收不良患病率的患病受试者中，阈值乳糖剂量明显较低。强调了乳糖吸收不良在肠易激综合征中的发病机制作用，以及个人乳糖耐受性的重要性。
