Berglund Joseph D, Galis Zorina S
Department of Medicine, Emory University, 1639 Pierce Drive-WMB, Atlanta, GA 30322, USA.
Br J Pharmacol. 2003 Oct;140(4):627-36. doi: 10.1038/sj.bjp.0705457.
Inadequate vascular perfusion leads to fatal heart attacks, chronic ulcers, and other serious clinical conditions. The body's capacity to restore vascular perfusion through angiogenesis and arteriogenesis is often impaired by pre-existing disease, and availability of native replacements for nonfunctional arteries is limited in many patients. Thus, recreating blood vessels of various calibres through novel engineering technologies has emerged as a radical option among therapeutic strategies for revascularization. Ranging from artificial, recycled or reassembled natural conduits to sophisticated microdevices, we refer to these as 'designer blood vessels'. Our common efforts to continuously improve vascular replacement design have provided many clues about our own blood vessels, but nature's ability to create nonthrombogenic, immunocompatible, strong, yet biologically responsive blood vessels remains unparalleled. Just as art reproductions never equal the original masterpiece, designer blood vessels may never attain nature's perfection. Nevertheless, they will provide a valuable option as long as they come close enough and are available to many.
血管灌注不足会导致致命的心脏病发作、慢性溃疡和其他严重的临床病症。机体通过血管生成和动脉生成来恢复血管灌注的能力常常会因既有疾病而受损，而且对于许多患者而言，功能性动脉的天然替代物的可用性有限。因此，通过新型工程技术再造各种管径的血管已成为血管再通治疗策略中的一种激进选择。从人工的、回收利用的或重新组装的天然管道到精密的微型装置，我们将这些称为“定制血管”。我们不断改进血管替代物设计的共同努力为了解我们自身的血管提供了许多线索，但大自然创造出无血栓形成、免疫相容、坚固且具有生物反应性的血管的能力仍然是无与伦比的。正如艺术复制品永远无法等同于原作杰作一样，定制血管可能永远无法达到大自然的完美程度。然而，只要它们足够接近完美并且可供许多人使用，它们就将提供一种有价值的选择。
