Dot D, Miró J, Fuentes-Arderiu X
Laboratori d'Anàlisis Clíniques, Hospital de Viladecans, Spain.
Scand J Clin Lab Invest. 1992 Nov;52(7):607-11. doi: 10.3109/00365519209115503.
The biological variation of the blood concentration and number fraction of the different kinds of leukocytes have been estimated, over a one-year period in a group of 19 women and 20 men, apparently healthy volunteers. All measurements have been performed with a Toa E-5000 haematological analyser. The medians of the within-subject biological coefficients of variation, separated by sex when significant differences exist, are the following for concentrations: 9.4% in men and 15.4% in women for the leukocytes, 16.9% in men and 26.9% in women for the neutrophils, 12.3% for the lymphocytes, 14.9 for the basophils+eosinophils+monocytes (as measured by Toa E-5000); and for number fraction are the following: 8.6% for neutrophils, 0% in men and 7.2% in women for lymphocytes, and 16.7 for basophils+eosinophils+monocytes (as measured by Toa E-5000). With these data the index of individuality, the critical difference for significant change detection and the desirable imprecision have been calculated.
在一组19名女性和20名男性的明显健康志愿者中，对不同种类白细胞的血液浓度和数量分数的生物学变异进行了为期一年的评估。所有测量均使用东亚E - 5000血液分析仪进行。当存在显著差异时，按性别分开的受试者内生物学变异系数的中位数如下：白细胞浓度方面，男性为9.4%，女性为15.4%；中性粒细胞浓度方面，男性为16.9%，女性为26.9%；淋巴细胞浓度为12.3%；嗜碱性粒细胞+嗜酸性粒细胞+单核细胞浓度（通过东亚E - 5000测量）为14.9%；数量分数方面：中性粒细胞为8.6%，淋巴细胞男性为0%，女性为7.2%，嗜碱性粒细胞+嗜酸性粒细胞+单核细胞（通过东亚E - 5000测量）为16.7%。利用这些数据计算了个体性指数、显著变化检测的临界差异和理想不精密度。
