Soroka N F
Ter Arkh. 1992;64(5):17-20.
The content of cyclic nucleotides (cAMP and cGMP) in plasma (or blood), synovial fluid and neutrophils was measured in 151 patients suffering from rheumatoid arthritis (RA) as was the content of prostaglandins (E2 and F2 alpha), ACTH, hydrocortisone, antioxidant system enzymes (superoxide dismutase and catalase). Part of the patients were examined over time. Relative stability of certain characteristics (the content of hydrocortisone, neuropeptides, superoxide dismutase, and so forth) was established throughout a long time, irrespective of the process activity or treatment provided. It is concluded that every RA patient has a "weak" biochemical component of his own, reflecting the activity or power of one or another regulatory system.
对151例类风湿性关节炎（RA）患者的血浆（或血液）、滑液和中性粒细胞中的环核苷酸（cAMP和cGMP）含量以及前列腺素（E2和F2α）、促肾上腺皮质激素、氢化可的松、抗氧化系统酶（超氧化物歧化酶和过氧化氢酶）的含量进行了测定。部分患者进行了长期检查。某些特征（氢化可的松、神经肽、超氧化物歧化酶等的含量）在很长一段时间内保持相对稳定，与疾病活动度或所接受的治疗无关。得出的结论是，每位RA患者都有自身的“微弱”生化成分，反映了一种或另一种调节系统的活性或强度。
