Willoughby K, Kelly D F, Lyon D G, Wells G A
Department of Veterinary Clinical Science, University of Liverpool.
Vet Rec. 1992 Nov 7;131(19):431-4. doi: 10.1136/vr.131.19.431.
A captive adult puma developed ataxia, a hypermetric gait and whole body tremor. The signs progressed over a period of six weeks. Histopathological examination following euthanasia demonstrated spongiform encephalopathy, gliosis and mild non-suppurative meningoencephalitis. Immunostaining with a polyclonal antiserum revealed prion protein (PrP) associated with these changes in sections of cervical spinal cord and medulla. This is the first confirmed case of a scrapie-like spongiform encephalopathy described in a non-domestic cat in the United Kingdom.
一只圈养的成年美洲狮出现共济失调、步幅过大的步态和全身震颤。这些症状在六周内逐渐发展。安乐死后的组织病理学检查显示有海绵状脑病、胶质细胞增生和轻度非化脓性脑膜脑炎。用多克隆抗血清进行免疫染色显示，在颈脊髓和延髓切片中，朊病毒蛋白（PrP）与这些变化有关。这是英国首例在非家猫中确诊的类羊瘙痒症海绵状脑病病例。
