Nygaard K, Hagen S, Hansen H S, Hatlevoll R, Hultborn R, Jakobsen A, Mäntyla M, Modig H, Munck-Wikland E, Rosengren B
Department of Surgery, Aker Hospital, Oslo, Norway.
World J Surg. 1992 Nov-Dec;16(6):1104-9; discussion 1110. doi: 10.1007/BF02067069.
In a prospective multicenter study, 186 patients with squamous cell esophageal carcinoma, who after evaluation were considered suitable for surgery, were randomized to 4 treatment groups: Group 1, surgery alone; Group 2, pre-operative chemotherapy (cisplatin and bleomycin) and surgery; Group 3, pre-operative irradiation (35 Gy) and surgery; Group 4, pre-operative chemotherapy, radiotherapy, and surgery. Three-year survival was significantly higher in the pooled groups receiving radiotherapy as compared with the pooled groups not receiving radiotherapy. Comparison of the groups having pre-operative chemotherapy with those not having chemotherapy showed no significant difference in survival. Female patients had a significantly better survival than males. The results indicate that pre-operative irradiation had a beneficial effect on intermediate term survival, whereas the chemotherapy regime used did not influence survival.
在一项前瞻性多中心研究中，186例经评估认为适合手术的食管鳞状细胞癌患者被随机分为4个治疗组：第1组，单纯手术；第2组，术前化疗（顺铂和博来霉素）加手术；第3组，术前放疗（35 Gy）加手术；第4组，术前化疗、放疗加手术。与未接受放疗的合并组相比，接受放疗的合并组三年生存率显著更高。术前化疗组与未化疗组的生存率比较无显著差异。女性患者的生存率显著优于男性。结果表明，术前放疗对中期生存有有益影响，而所用化疗方案不影响生存。
