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含二糖核苷的寡核苷酸:合成、物理化学性质及底物特性

Oligonucleotides containing disaccharide nucleosides: synthesis, physicochemical, and substrate properties.

作者信息

Mikhailov S N, Efimtseva E V, Ermolinsky B S, Bobkov G V, Andreeva O I, Golubeva A S, Kochetkov S N, Van Aerschot A, Schepers G, Herdewijn P

机构信息

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1117-8. doi: 10.1081/NCN-120022750.

DOI:10.1081/NCN-120022750
PMID:14565358
Abstract

The efficient synthesis of oligonucleotides containing 2'-O-beta-D-ribofuranosyl (and beta-D-ribopyranosyl)nucleosides, 2'-O-alpha-D-arabinofuranosyl (and alpha-L-arabinofuranosyl)nucleosides. 2'-O-beta-D-erythrofuranosylnucleosides, and 2'-O-(5'-amino-5-deoxy-beta-D-ribofuranosyl)nucleosides have been developed.

摘要

已开发出含有2'-O-β-D-呋喃核糖基(和β-D-吡喃核糖基)核苷、2'-O-α-D-阿拉伯呋喃糖基(和α-L-阿拉伯呋喃糖基)核苷、2'-O-β-D-赤藓呋喃糖基核苷以及2'-O-(5'-氨基-5-脱氧-β-D-呋喃核糖基)核苷的寡核苷酸的高效合成方法。

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Oligonucleotides containing disaccharide nucleosides: synthesis, physicochemical, and substrate properties.含二糖核苷的寡核苷酸:合成、物理化学性质及底物特性
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