2'-氨基-LNA的合成改进
Improved synthesis of 2'-amino-LNA.
作者信息
Christensen Signe M, Rosenbohm Christoph, Sørensen Mads, Larsen Lotte-Emilie, Wengel Jesper, Koch Troels
机构信息
Cureon A/S, Copenhagen, Denmark.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1131-3. doi: 10.1081/NCN-120022818.
PMID:14565362
Abstract
2'-Amino-LNA phosphoramidite (10) was synthesised by means of a new strategy, which is convergent with the synthesis of 2'-oxy-LNA up until a late stage intermediate (1).
摘要
2'-氨基-LNA亚磷酰胺（10）通过一种新策略合成，该策略与2'-氧代-LNA的合成直到后期中间体（1）都是汇聚式的。
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