金奈青光眼研究的方法与设计。
Methods and design of the Chennai Glaucoma Study.
作者信息
Arvind Hemamalini, Paul Pradeep G, Raju Prema, Baskaran M, George Ronnie, Balu Sukumar, Sripriya Sarangapani, Ramesh S Ve, Mukesh Bickol N, Vijaya Lingam, Kumaramanickavel Govindasamy, McCarty Catherine
机构信息
Glaucoma Project, Vision Research Foundation, Chennai, Sankara Nethralaya, India.
出版信息
Ophthalmic Epidemiol. 2003 Dec;10(5):337-48. doi: 10.1076/opep.10.5.337.17320.
PURPOSE
To describe the methodology of a population-based study to estimate the prevalence of glaucoma in a rural and urban South Indian population and to study the genetics of glaucoma in this population.
METHODS
A sample size of 4758 each for rural and urban populations in the Indian state of Tamil Nadu was calculated. Eligible subjects aged 40 years and above from the rural study area covering 32 contiguous villages and the urban area comprising five random clusters in Chennai city are enumerated. Demographic data are collected in the field. A detailed clinical examination, including glaucoma diagnostic procedures, is conducted at the examination centre. Pedigree ascertainment and genetic studies are performed for subjects with occludable angles or glaucoma. Data are recorded in a computerised database.
CONCLUSIONS
This study is expected to result in an estimation of the prevalence and a better understanding of the genetics of glaucoma in this region.
目的
描述一项基于人群的研究方法，以估计印度南部城乡人群中青光眼的患病率，并研究该人群中青光眼的遗传学。
方法
计算了印度泰米尔纳德邦农村和城市人群各4758人的样本量。对来自覆盖32个相邻村庄的农村研究区域以及金奈市五个随机集群组成的城市地区40岁及以上的符合条件的受试者进行了计数。在实地收集人口统计学数据。在检查中心进行详细的临床检查，包括青光眼诊断程序。对具有可闭角或青光眼的受试者进行家系确定和遗传学研究。数据记录在计算机化数据库中。
结论
预计这项研究将得出该地区青光眼患病率的估计值，并更好地了解青光眼的遗传学。
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