Soto L F, Miller C H, Ognibere A J
Northeastern Ohio Universities College of Medicine.
Postgrad Med. 1993 Jun;93(8):227-9, 232. doi: 10.1080/00325481.1993.11701728.
Clinicians should be aware of the complications of rhabdomyolysis in patients who ingest doxylamine succinate and other over-the-counter antihistamines. The easy availability of these substances increases the potential not only for intentional overdose by adults but also for inadvertent ingestion by children. Prompt intervention and careful assessment of renal function, urinary output, and serum creatine kinase levels may represent the difference between an uncomplicated course and acute renal failure.
临床医生应意识到，服用琥珀酸多西拉敏和其他非处方抗组胺药的患者会出现横纹肌溶解症并发症。这些药物容易获取，不仅增加了成年人故意过量服药的可能性，也增加了儿童意外摄入的可能性。及时干预并仔细评估肾功能、尿量和血清肌酸激酶水平，可能是病情平稳发展与急性肾衰竭的区别所在。
