酵母中维生素B1的生物合成。嘧啶单元由吡哆醇和组氨酸衍生而来。尿刊酸的中间体作用。
Biosynthesis of vitamin B1 in yeast. Derivation of the pyrimidine unit from pyridoxine and histidine. Intermediacy of urocanic acid.
作者信息
Zeidler Johannes, Sayer Brian G, Spenser Ian D
机构信息
Department of Chemistry, McMaster University, Hamilton, Ontario, Canada L8S 4M1.
出版信息
J Am Chem Soc. 2003 Oct 29;125(43):13094-105. doi: 10.1021/ja030261j.
PMID:14570482
Abstract
Incorporation studies with 13C-, 15N-, and 2H-labeled substrates, followed by NMR analysis, show that the pyrimidine unit of thiamin (Vitamin B1) originates from a C5N fragment, derived from C-2',2,N,C-6,5,5' of pyridoxol (Vitamin B6) and an N-C-N fragment derived from L-histidine. Urocanic acid serves as an intermediate on the route of the N-C-N fragment of histidine into the thiamin pyrimidine.
摘要
用13C、15N和2H标记的底物进行掺入研究，随后进行核磁共振分析，结果表明硫胺素（维生素B1）的嘧啶单元源自一个C5N片段，该片段来自吡哆醇（维生素B6）的C-2′、2、N、C-6、5、5′，以及一个源自L-组氨酸的N-C-N片段。尿刊酸是组氨酸的N-C-N片段进入硫胺素嘧啶途径的中间体。
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