Althoff J, Grandjean C, Pour P
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977 Nov 18;90(2):119-26. doi: 10.1007/BF00285318.
The present investigations showed that assumed and established metabolites of dipropylnitrosamine and dibutylnitrosamine reach the Syrian hamster fetus after subcutaneous (s.c.) treatment of their mothers (at day 14 of gestation). The compounds [2-hydroxypropylpropylnitrosamine, HPPN; 2-oxopropylpropylnitrosamine, OPPN; methylpropylnitrosamine, MPN; N-nitrosobis(2-hydroxypropyl)amine, BHP; and 4-hydroxybutylbutylnitrosamine, HBBN] were still present in the examined tissue (maternal blood, placenta, fetus, amniotic fluid) 4--6 h after s.c. injection. The overall incidence of transplacentally induced tumors was lower in the F1- than in the P-generation and comparatively longer latencies were also observed in the F1- generation. However, in some groups low incidences were found of tumors which did not occur in the mothers (i.e., nasal cavities: BHP, HBBN; trachea: HBBN; lungs: HPPN, BHP, HBBN; liver: OPN, MPN, BHP, HBBN). Compared to exposure at early gestation, the transplacental carcinogenic effect increased at day 14 of gestation. Neoplasms originating in other organs were not associated with a transplacental effect of the examined nitrosamines.
目前的研究表明，在叙利亚仓鼠母亲于妊娠第14天进行皮下注射后，二丙基亚硝胺和二丁基亚硝胺假定的和已确定的代谢产物会到达胎儿体内。皮下注射4至6小时后，这些化合物（2-羟丙基丙基亚硝胺，HPPN；2-氧代丙基丙基亚硝胺，OPPN；甲基丙基亚硝胺，MPN；N-亚硝基双（2-羟丙基）胺，BHP；以及4-羟基丁基丁基亚硝胺，HBBN）仍存在于所检查的组织（母体血液、胎盘、胎儿、羊水）中。经胎盘诱导的肿瘤在F1代中的总体发生率低于P代，并且在F1代中也观察到相对较长的潜伏期。然而，在一些组中发现了母亲未发生的低发生率肿瘤（即鼻腔：BHP、HBBN；气管：HBBN；肺：HPPN、BHP、HBBN；肝脏：OPN、MPN、BHP、HBBN）。与妊娠早期暴露相比，在妊娠第14天经胎盘致癌作用增强。起源于其他器官的肿瘤与所检查亚硝胺的经胎盘作用无关。
