Itoh Takuya, Kinoshita Masahiro, Aoki Shunji, Kobayashi Motomasa
Graduate School of Pharmaceutical Sciences, Osaka University, Yamada-oka 1-6, Suita, Osaka 565-0871, Japan.
J Nat Prod. 2003 Oct;66(10):1373-7. doi: 10.1021/np030212k.
A novel anthracycline, komodoquinone A (1), and its aglycone, komodoquinone B (2), were isolated from the solid-state fermentation of the marine Streptomyces sp. KS3, which was isolated from marine sediment. The absolute stereostructures of 1 and 2, except for the sugar portion, were elucidated on the basis of chemical and physicochemical evidence. Komodoquinone A (1) is a unique anthracycline, in which a new amino sugar is connected to the D-ring of the anthracyclinone skeleton, and was found to induce neuronal cell differentiation in the neuroblastoma cell line, Neuro 2A.
从海洋沉积物中分离出的海洋链霉菌属菌株KS3的固态发酵产物中，分离得到了一种新型蒽环类化合物——科莫多醌A（1）及其苷元科莫多醌B（2）。基于化学和物理化学证据阐明了1和2除糖部分外的绝对立体结构。科莫多醌A（1）是一种独特的蒽环类化合物，其中一个新的氨基糖连接到蒽环酮骨架的D环上，并且发现它能诱导神经母细胞瘤细胞系Neuro 2A中的神经元细胞分化。
