N-亚硝基吡咯烷的致癌性：大鼠剂量反应研究
Carcinogenicity of N-nitrosopyrrolidine: dose-response study in rats.
作者信息
Preussmann R, Schmähl D, Eisenbrand G
出版信息
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977 Nov 18;90(2):161-6. doi: 10.1007/BF00285322.
PMID:145756
Abstract
Results from a dose-response study in rats are reported, in which daily oral doses of 10, 3, 1, and 0.3 mg/kg bodyweight/day respectively were administered. The three highest dose levels resulted in incidences of liver cancer of 46, 84, and 32% respectively. In the lowest dose group (0.3 mg/kg/day) no statistically significant increase in tumor rate compared to untreated controls was found.
摘要
报告了一项大鼠剂量反应研究的结果，其中分别给予每日口服剂量为10、3、1和0.3毫克/千克体重/天。三个最高剂量水平导致肝癌发生率分别为46%、84%和32%。在最低剂量组（0.3毫克/千克/天）中，与未处理的对照组相比，未发现肿瘤发生率有统计学上的显著增加。
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