Wolfram Roswitha M, Chehne Fahdi, Oguogho Anthony, Sinzinger Helmut
Department of Angiology, University of Vienna, Austria.
Life Sci. 2003 Nov 21;74(1):47-53. doi: 10.1016/j.lfs.2003.06.020.
The biological effects of smoking water pipe on haemostasis and the eicosanoid system is unknown. Water pipe smoking is familiar to approximately 1 billion people around the world. Considering this quite impressive number, we investigated the potential effect of smoking the Narghile on oxidation injury by monitoring parameters of the (iso)eicosanoid system. Patients were allowed to smoke a water pipe once daily for 14 days. Blood was drawn from 7 healthy adult non-cigarette smoking male volunteers before and immediately after the first smoking of the water pipe and additionally after 6 hours. One and 2 weeks thereafter, blood was drawn again before and after smoking. A total of 7 blood samples was drawn during the study, and parameters of in vivo oxidation injury (8-epi-PGF2alpha, malondialdehyde [MDA]) and haemostasis (11-dehydro-thromboxane B2 [11-DH-TXB2]) were investigated. A single smoking session increased oxidation injury (8-epi-PGF2alpha: p=0.03; MDA: p=0.001) and 11-DH-TXB2 (p=0.00003) significantly, and repeated daily smoking induced a persistent long-lasting oxidation injury reflected by elevated prevalues but a smaller response to the actual water pipe smoke. These findings indicate a significant increase of in vivo oxidative stress by regular water pipe smoking.
水烟对止血和类花生酸系统的生物学效应尚不清楚。水烟吸食在全球约10亿人当中较为常见。鉴于这一相当可观的数字，我们通过监测（异）类花生酸系统的参数，研究了吸食纳吉勒水烟对氧化损伤的潜在影响。患者被允许每天吸食一次水烟，持续14天。在首次吸食水烟之前、刚吸食完水烟之后以及6小时后，从7名健康的成年非吸烟男性志愿者身上采集血液。在那之后的1周和2周，再次在吸食水烟前后采集血液。在研究期间共采集了7份血样，并对体内氧化损伤参数（8-表前列腺素F2α、丙二醛[MDA]）和止血参数（11-脱氢血栓素B2[11-DH-TXB2]）进行了研究。单次吸食水烟显著增加了氧化损伤（8-表前列腺素F2α：p = 0.03；MDA：p = 0.001）和11-DH-TXB2（p = 0.00003），并且每日重复吸食会导致持续的长期氧化损伤，表现为预先值升高，但对实际水烟烟雾的反应较小。这些发现表明，经常吸食水烟会使体内氧化应激显著增加。
