Rodríguez María C, Sáiz María P, Mitjavila María T
Department de Fisiologia, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain.
Lipids. 2003 Aug;38(8):821-6. doi: 10.1007/s11745-003-1131-8.
Inflammatory disorders are associated with a decrease in iron absorption because of the blockade of iron in storage organs. Fish oils, rich in n-3 PUFA, are used to prevent and treat inflammatory disorders and increase iron absorption in noninflamed rats. Here we examine whether n-3 PUFA prevent inflammation-related hypoferremia. Two groups of rats were fed isoenergetic semipurified diets (a standard diet and a sardine oil-rich diet). A carrageenan granuloma was induced in half of the rats of each dietary group. Ferrokinetic studies using 59Fe, hematological analyses, and iron store evaluation were performed in noninflamed and inflamed rats. Although dietary n-3 PUFA increased 59Fe absorption in carageenan-treated rats, they did not restore the hypoferremia associated with inflammation, which is due to several mechanisms. Among these mechanisms, the blockade of iron in storage organs is relevant. However, this blockade was less evident in the spleen of inflamed rats fed the sardine oil diet.
炎症性疾病与铁吸收减少有关，这是因为储存器官中铁的蓄积。富含n-3多不饱和脂肪酸（PUFA）的鱼油可用于预防和治疗炎症性疾病，并增加未发炎大鼠的铁吸收。在此，我们研究n-3多不饱和脂肪酸是否能预防炎症相关的低铁血症。将两组大鼠喂以等能量的半纯化日粮（标准日粮和富含沙丁鱼油的日粮）。每组日粮喂养的大鼠中各有一半诱发角叉菜胶肉芽肿。对未发炎和发炎的大鼠进行了使用59Fe的铁动力学研究、血液学分析以及铁储存评估。尽管日粮中的n-3多不饱和脂肪酸增加了角叉菜胶处理大鼠对59Fe的吸收，但它们并未恢复与炎症相关的低铁血症，这是由多种机制导致的。在这些机制中，储存器官中铁的蓄积是相关因素。然而，在喂食沙丁鱼油日粮的发炎大鼠脾脏中，这种蓄积不太明显。
