Cvetkovic Dusica
Ovarian Cancer Program, Division of Medical Science, Fox Chase Cancer Center, Philadelphia, PA, USA.
Reprod Biol Endocrinol. 2003 Oct 7;1:68. doi: 10.1186/1477-7827-1-68.
Ovarian cancer represents the most lethal of the gynecological neoplasms. The molecular and genetic events associated with early ovarian oncogenesis are still largely unknown, thus contributing to the lack of reliable biomarkers for disease detection. Since the majority of ovarian tumors are diagnosed at an advanced stage, the availability of early ovarian cancer tissue samples for molecular analyses is very limited. In this review, problems encountered in the study of early ovarian cancer are presented, along with the controversies concerning precursor lesions and stepwise progression towards ovarian malignancy. Experimental modeling in the development of ovarian cancer is also described, as well as genetic and epigenetic alterations associated with early ovarian cancer. Lastly, examples of technological advances in the study of early ovarian cancer are discussed. Hopefully, the increasing knowledge about molecular and genetic events involved in the early stages of ovarian tumorigenesis will provide the basis for management of ovarian cancer in the future.
卵巢癌是最致命的妇科肿瘤。与早期卵巢肿瘤发生相关的分子和遗传事件在很大程度上仍不清楚，这导致缺乏用于疾病检测的可靠生物标志物。由于大多数卵巢肿瘤在晚期才被诊断出来，用于分子分析的早期卵巢癌组织样本非常有限。在这篇综述中，介绍了早期卵巢癌研究中遇到的问题，以及关于前驱病变和向卵巢恶性肿瘤逐步发展的争议。还描述了卵巢癌发展过程中的实验模型，以及与早期卵巢癌相关的遗传和表观遗传改变。最后，讨论了早期卵巢癌研究中的技术进步实例。希望对卵巢肿瘤发生早期所涉及的分子和遗传事件的不断了解，将为未来卵巢癌的管理提供依据。
