Pol Chetan A, Ghige Suvarna K, Gosavi Suchitra R
Department of Oral Pathology & Microbiology, Government Dental College & Hospital, Nagpur, Maharashtra, India.
Int Dent J. 2015 Feb;65(1):11-4. doi: 10.1111/idj.12125. Epub 2014 Sep 25.
Oral lichen planus (OLP) is a common chronic inflammatory immune-mediated disease with an aetiopathogenesis associated with cell-mediated immunological dysfunction. It is possible that oral mucosal viral infections, including human papilloma virus-16 (HPV-16) infection, may have a causative role in OLP pathogenesis.
To assess the prevalence of HPV-16 in histopathologically diagnosed specimens of OLP and to evaluate whether any clinical features (such as the localisation of specimens) or the age or gender of patients, are correlated with the presence of this virus.
This study was conducted on 30 specimens with a histopathological diagnosis of OLP, using the immunohistochemical marker HPV-16. Thirty normal oral mucosa specimens were also included as controls. Brown nuclear staining was accepted as positive for the HPV-16 antibody. The results were analysed using Fisher's exact test. P values<0.05 were considered to be significant.
Significant correlation (P=0.0001) was observed between HPV-16 infection and samples with OLP. No statistical conclusions could be drawn regarding age, gender, localisation and HPV-16 positivity.
Our study showed that HPV-16 may play a role in the pathogenesis of OLP. Taking into account the oncogenic potential of HPV-16, patients with OLP should be screened for the presence of this virus.
口腔扁平苔藓（OLP）是一种常见的慢性炎症性免疫介导疾病，其发病机制与细胞介导的免疫功能障碍有关。口腔黏膜病毒感染，包括人乳头瘤病毒16型（HPV-16）感染，可能在OLP发病机制中起致病作用。
评估HPV-16在经组织病理学诊断的OLP标本中的患病率，并评估是否有任何临床特征（如标本的定位）或患者的年龄、性别与该病毒的存在相关。
本研究对30例经组织病理学诊断为OLP的标本使用免疫组化标记物HPV-16进行检测。还纳入30例正常口腔黏膜标本作为对照。HPV-16抗体的棕色细胞核染色被视为阳性。结果采用Fisher精确检验进行分析。P值<0.05被认为具有统计学意义。
观察到HPV-16感染与OLP样本之间存在显著相关性（P=0.0001）。关于年龄、性别、定位和HPV-16阳性率，无法得出统计学结论。
我们的研究表明，HPV-16可能在OLP发病机制中起作用。考虑到HPV-16的致癌潜力，应对OLP患者进行该病毒存在情况的筛查。
