老年股骨颈骨折患者的维生素C缺乏与压疮
Vitamin C depletion and pressure sores in elderly patients with femoral neck fracture.
作者信息
Goode H F, Burns E, Walker B E
机构信息
St James's University Hospital, Leeds.
出版信息
BMJ. 1992 Oct 17;305(6859):925-7. doi: 10.1136/bmj.305.6859.925.
OBJECTIVE
To evaluate the contribution of specific nutritional deficiencies (as indicated by zinc; vitamin A, C, and E; albumin; and haemoglobin concentrations) to the risk of pressure sores.
DESIGN
Observational cohort study.
SETTING
St James's University Hospital, Leeds.
SUBJECTS
21 elderly patients presenting consecutively to the orthopaedic unit with femoral neck fracture.
MAIN OUTCOME MEASURE
Full thickness epidermal break over a pressure bearing surface.
RESULTS
10 patients (48%) developed a pressure sore during their hospital stay. Indices of zinc status and concentrations of albumin, haemoglobin, and vitamins A and E were similar in patients who developed a pressure sore and those who did not. Mean leucocyte vitamin C concentration, however, was 6.3 (SD 2.2) micrograms/10(8) cells in patients who developed a pressure sore as compared with 12.8 (4.6) micrograms/10(8) cells in patients who did not.
CONCLUSIONS
Low concentrations of leucocyte vitamin C appear to be associated with subsequent development of pressure sores in elderly patients with femoral neck fractures.
目的
评估特定营养缺乏（以锌、维生素A、C和E、白蛋白及血红蛋白浓度表示）对压疮风险的影响。
设计
观察性队列研究。
地点
利兹市圣詹姆斯大学医院。
研究对象
21例因股骨颈骨折连续入住骨科病房的老年患者。
主要观察指标
受压部位全层表皮破损。
结果
10例患者（48%）在住院期间发生了压疮。发生压疮的患者与未发生压疮的患者在锌状态指标、白蛋白、血红蛋白及维生素A和E浓度方面相似。然而，发生压疮的患者白细胞维生素C平均浓度为6.3（标准差2.2）微克/10⁸细胞，而未发生压疮的患者为12.8（4.6）微克/10⁸细胞。
结论
白细胞维生素C浓度低似乎与老年股骨颈骨折患者随后发生压疮有关。
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