Halma C, Breedveld F C, Daha M R, Blok D, Evers-Schouten J H, Hermans J, Pauwels E K, van Es L A
Department of Nephrology, University Hospital Leiden, The Netherlands.
Arthritis Rheum. 1991 Apr;34(4):442-52. doi: 10.1002/art.1780340409.
Using soluble 123I-labeled aggregates of human IgG (123I-AHIgG) as a probe, we examined the function of the mononuclear phagocyte system in 22 patients with systemic lupus erythematosus (SLE) and 12 healthy controls. In SLE patients, a decreased number of erythrocyte complement receptor type 1 was associated with less binding of 123I-AHIgG to erythrocytes and a faster initial rate of elimination of 123I-AHIgG (mean +/- SEM half-maximal clearance time 5.23 +/- 0.2 minutes, versus 6.58 +/- 0.2 minutes in the controls), with possible spillover of the material outside the mononuclear phagocyte system of the liver and spleen. However, multiple regression analysis showed that serum concentrations of IgG were the most important factor predicting the rate of 123I-AHIgG elimination. IgG concentration may thus reflect immune complex clearance, which in turn, would influence the inflammatory reaction, in SLE.
我们使用可溶性123I标记的人IgG聚集体（123I-AHIgG）作为探针，检测了22例系统性红斑狼疮（SLE）患者和12名健康对照者的单核吞噬细胞系统功能。在SLE患者中，红细胞补体1型受体数量减少与123I-AHIgG与红细胞的结合减少以及123I-AHIgG更快的初始清除率相关（平均±标准误半最大清除时间为5.23±0.2分钟，而对照组为6.58±0.2分钟），可能有物质溢出肝脏和脾脏的单核吞噬细胞系统。然而，多元回归分析表明，IgG血清浓度是预测123I-AHIgG清除率的最重要因素。因此，IgG浓度可能反映免疫复合物清除情况，而这反过来又会影响SLE中的炎症反应。
