Bardage Carola, Isacson Dag, Ring Lena, Bingefors Kerstin
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Blood Press. 2003;12(4):203-10. doi: 10.1080/08037050310002083.
The aim of this study was to determine the relationship between a psychometric health-related quality-of-life instrument (the SF-36)-and two health utility measures [the time trade-off (TTO) and rating scale (RS) methods) among hypertensives in a general population. In the analyses were adjusted for comorbidity. The study was based on a postal questionnaire that was sent to a random sample of 8000 inhabitants aged 20-84 years (response rate 68%) in Uppsala County, Sweden, in 1995. The results showed only a moderate correlation between the TTO and the RS methods. The different dimensions of SF-36 were overall lower correlated with the TTO method than with the RS method. Co-morbidity was not associated with the RS or the TTO method among hypertensives. The regression equations explained 58% of the variance in RS among hypertensives. The corresponding value for the TTO method was about 20%. In conclusion, our study found that among hypertensives the SF-36 is low to moderate correlated to the TTO and RS methods. Health utilities and psychometric measures represent different attributes of health. It is therefore important to be aware of the differences between psychometric and utility measures when interpreting results from studies using different methods. More work is needed to explicate if health utilities can be obtained from the SF-36.
本研究的目的是确定在普通人群的高血压患者中，一种与健康相关的心理测量生活质量工具（SF-36）与两种健康效用测量方法[时间权衡法（TTO）和评分量表法（RS）]之间的关系。分析中对合并症进行了校正。该研究基于1995年寄给瑞典乌普萨拉县8000名年龄在20 - 84岁居民的随机样本的邮政调查问卷（回复率68%）。结果显示TTO法和RS法之间只有中等程度的相关性。SF-36的不同维度与TTO法的总体相关性低于与RS法的相关性。在高血压患者中，合并症与RS法或TTO法均无关联。回归方程解释了高血压患者中RS方差的58%。TTO法的相应值约为20%。总之，我们的研究发现，在高血压患者中，SF-36与TTO法和RS法的相关性较低至中等。健康效用和心理测量指标代表了健康的不同属性。因此，在解释使用不同方法的研究结果时，了解心理测量指标和效用指标之间的差异很重要。若要从SF-36中获取健康效用，还需要开展更多工作。
